Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives. Contributors are world leaders in their fields of study and represent prestigious academic and research institutionsReview articles vary vastly in scope: some focus on a narrowly defined scientific problem of one particular virus with careful introduction for the non-specialist; others are essays in general and comparative virology with forays into specific viral species or moleculesThe different perspectives complement each other and collectively the contributions provide an impression of the fast-moving frontlines of virology while showing how the problems have evolvedStructural data are presented through high-quality illustrations INDICE: Unity in diversity: Shared mechanism of entry among paramyxoviruses Jean-Louis Palgen, Eric M. Jurgens, Anne Moscona, Matteo Porotto and Laura M. PalermoAlphavirus entry into host cells Ricardo Vancini, Raquel Hernandez and Dennis BrownThe mechanism of HCV entry into host cellsFrancois-Loïc CossetThe evolution of HIV interactions with coreceptors and mannose C-type lectin receptors Marie Borggren and Marianne JanssonA game of numbers: the stoichiometry of antibody-mediated neutralization of flavivirus infection Theodore C. Pierson and Michael S. DiamondTRIM21-dependent Intracellular antibody neutralization of virus infection William A. McEwan and Leo C. JamesPicornavirus-host interactions to construct viral secretory membranesAlexander GreningerRetroviral factors promoting infectivity Emilia Cristiana Cuccurullo, Chiara Valentini and Massimo PizzatoThe cytoplasmic tail of retroviral envelope glycoproteins Philip R. Tedbury and Eric O. FreedThe assembly and egress of HIV (tentative title) David Nkwe and Mark MarshMolecular determinants of the ratio of inert to infectious virus particlesP.J. KlasseThe role of chance in primate lentiviral infectivity: from protomer to host organism Roland R. Regoes and Carsten MagnusVirus-encoded 7 transmembrane receptors Ann-Sofie Mølleskov-Jensen, Martha Trindade Oliveira, Helen Elizabeth Farrell & Nick Davis-PoynterEBV, the human host and the 7TM receptors: defense or offense?Kristine Niss Arfelt, Suzan Fares and Mette M. Rosenkilde
- ISBN: 978-0-12-802461-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 300
- Fecha Publicación: 15/01/2015
- Nº Volúmenes: 1
- Idioma: Inglés