Signal Transduction, Third Edition is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. This book will serve as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Includes up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention Provides in-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors, tyrosine protein kinases and adaptive immunity, and intracellular calciumPresents extensive conceptual color artwork to assist with comprehension of key topics Includes instrumental margin notes that highlight milestones in signaling mechanisms INDICE: Chapter 1 Prologue: signal transduction from a historical perspective Chapter 2 An introduction to signal transduction Chapter 3 Regulation of muscle contraction by receptors Chapter 4 Cholingergic signalling and muscle contraction Chapter 5 Sensory signal processing: visual transduction and olfaction Chapter 6 Intracellular calcium Chapter 7 Bringing the signal into the nucleus: regulation of gene expression Chapter 8 Nuclear receptors Chapter 9 Protein kinase C and cell polarity Chapter 10 Signalling pathways operated by receptor protein tyrosine kinases Chapter 11 Signalling transduction to and from adhesion molecules Chapter 12 WNT signalling and the regulation of cell adhesion and differentiation Chapter 13 Activation of the innate immune system: the toll-like receptor and signalling through ubiquitylation Chapter 14 Chemokines and traffic of white blood cells Chapter 15 Cytoplasmic tyrosine kinases, NFAT and adaptive immunity Chapter 16 Insulin signalling Chapter 17 Signalling through receptor serine/threonine kinases Chapter 18 Protein phosphates Chapter 19 Signalling through the Notch receptor
- ISBN: 978-0-12-394803-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 848
- Fecha Publicación: 26/11/2015
- Nº Volúmenes: 1
- Idioma: Inglés