Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growthCovers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseasesIncludes commonly used methods to study ribosomes, such as polysome preparation, RNA analysis and proteomics, CryoEM, and Cell-free assays along with proper illustrations INDICE: 1. Introduction to ribosome factory, origin and evolution of translation (+ Mitoribosomes) 2. Ribosome - subunit structure, RNA and protein components 3. rDNA gene structure, transcription and their co-regulation (+ Nucleolar dynamics) 4. Ribosomal proteins - their balanced production 5. Ribosome cycle - assembly, degradation and recycling (+ ubiquitination) 6. Ribosomal biogenesis, Cell growth and Cell cycle 7. Ribosomal protein dynamics in Embryonic stem cells / during development 8. Protein synthesis - Translation control 9. Protein folding on ribosomes 10. Ribosomal control of viral RNA translation 11. Drug-induced Ribosomal frameshifting 12. Ribosome inhibition by antibiotics and other compounds 13. Ribosome and Cancer, Ribosomal proteins as tumor suppressors, Ribosomopathies 14. Ribosome profiling - Polysome preparation, RNA analysis and proteomics 15. The role of ribosome biogenesis in aging 16. CryoEM and Cell free assays

• ISBN: 978-0-12-816364-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/11/2019
• Nº Volúmenes: 1
• Idioma: Inglés