Stroke is a major cause of death and disability in the U.S. and worldwide. A variety of pathophysiologic episodes or cellular medications occur following astroke, and knowledge of these aftermath events can lead to potential therapeutic strategies that may reverse or attenuate stroke injury. Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion. Details the cellular events that occur following stroke. For the first time, the dyshomeostasis and pathophysiological actions of these metals in strokeare discussed systematically in one volume. Many metals function as co-factors in cellular and genetic signaling and, therefore, have important roles in biochemistry ranging from essential to toxic. INDICE: Preface. Metal Ions In Stroke Pathophysiology. Mechanisms Of Calcium Influx Following Stroke. Mitochondrial Ca2+ Dysregulation During Stroke AndCell Death. Calcium Channel Blockers And Stroke Prevention. Calcium Dyshomeostasis In Astrocytes After Ischemia. Calcium Signaling At The Blood-Brain Barrier In Stroke. Zinc Overload In Stroke. Intracellular Zinc Liberation: A Trigger For Oxidative Stress Induced Toxicity To Neurons And Neuroglia. Zinc In Stroke: Time For A New Approach?. Exploring The Zinc Metallome Of Cultured Cortical Neurons Using Synchroton Radiation X-Ray Fluorescence Microscopy. Iron Neurotoxicity In Ischemic And Hemorrhagic Stroke. Implication Of Oxidative Stress And “Labile Iron” In The Molecular Mechanisms Of Ischemic Stroke. The Role Of Iron In Brain Following Subarachnoid Hemorrhage. Iron Chelating Therapy In Stroke. Iron Chelating Therapy In Stroke. The Role Of Na+/Ca2+ Countertransport And Other Na+-Entry Routes In The Pathophysiology Of Stroke. Sodium And Potassium MRI In Cerebral Ischemia. The Impact Of Extracellular Potassium AccumulationIn Stroke. Potassium And Mitochondria. Role Of A Changing Membrane Potential (Em) And Matching Blood Flow With Neuronal Activity. The Role Of Potassium In Stroke, Cardiovascular Disease And Hypertension. The Role Of Magnesium In The Pathophysiology And Treatment Of Stroke And Other Neurological Injuries. The Role Of Magnesium In The Pathophysiology And Treatment Of Stroke And Other Neurological Injuries. Magnesium And Neuroprotection In Stroke. Magnesium In Ischemic Stroke And Subarachnoid Hemorrhage. Selenium And Selenoproteins In Neuroprotection And Neuronal Cell Death. Selenium As A Potential Treatment In CardiacArrest Induced Global Cerebral Ischemia. The Neurochemical Alterations Associated With Manganese Toxicity. Manganese Speciation Related To Neurotoxicity InHumans. The Role Of Mitochondrial Oxidative Stress And ATP Depletion In The Pathology Of Manganese Toxicity. Copper And Alzheimer Disease: The Good, The Bad And The Ugly. Conjecturable Role Of Aluminum In Pathophysiology Of Stroke. Chronic Arsenic Poisoning And Increased Risk Of Stroke. Aspects Of Cadmium Neurotoxicity. Cadmium Neurotoxicity And Its Role In Brain Disorders. The Role Of Mercury And Cadmium In Cardiovascular Disease, Hypertension, And Stroke. Nickel Modulation Of Voltage- And Ligand-Gated Ionic Channels In Neurons.
- ISBN: 978-1-4419-9662-6
- Editorial: Springer US
- Encuadernacion: Cartoné
- Páginas: 843
- Fecha Publicación: 31/05/2012
- Nº Volúmenes: 1
- Idioma: Inglés