Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, as well as characteristic mechanisms. This book also explores innovative therapeutic strategies in the preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance includes contributions from worldwide leading experts in the field. This book helps readers embrace the new hope to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cellsIncludes comprehensive coverage of current therapeutic strategies targeting cancer stem cellsDeepens a reader's technical expertise in cancer stem cell biology INDICE: Foreword by Jane Visvader and Stanton Gerson Section I. CSC Overview and Methodology 1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman 2. Overview: Cancer Stem Cell Self-Renewal Maider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke 3. Enrichment and Interrogation of Cancer Stem Cells Awad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin Lathia Section II. CSCs in Representative Organ systems 4. Critical Updates to the Leukemia Stem Cell Model Yogen Saunthararajah 5. Breast cancer stem cells and the move toward high resolution stem cell systems Benjamin T. Spike 6. Lung Cancer Stem Cells:  Drivers of Genetically and Histologically Complex Disease Christine M. Fillmore and Carla F. Kim 7. Colorectal cancer stem cells Sumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O'Brien 8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic? Antonina Kurtova and Keith Syson Chan 9. Cancer Stem Cells as New therapeutic Targets for Ovarian Cancer Yinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. Nephew Section III. CSC Features and Mechanisms 10. Understanding Cancer Cells of Origin in Cutaneous Tumors Hyeongsun Moon, Leanne R. Donahue, Andrew C. White 11. Asymmetric Division of Cancer Stem Cells Claudia Petritsch and Xiling Shen 12. Metastasis and Metastatic Cells:  A Historical Perspective and Current Analysis   Kiera Rycaj and Dean G. Tang 13. Metastasis and Evasion from the Host Immune Responses Avijeet Chopra, Xia Liu, Huiping Liu 14. Cancer Stem Cells and Tumor Associated Macrophages Wenchao Zhou and Shideng Bao 15. The Mechanisms of Therapy Resistance in Cancer Stem Cells Chi-Hsuan Chang and Jeffrey M. Rosen 16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancer Praveena S. Thiagarajan, Justin D. Lathia, and Ofer Reizes Section IV. Clinical Applications 17. From Research to the Clinic: Targeting Stem Cell Pathways in Cancer Austin Gurney and Timothy Hoey 18. Targeted Therapies for Glioma Stem Cells Swetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan 19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applications Molly Kozminsky and Sunitha Nagrath

• ISBN: 978-0-12-803892-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 536
• Fecha Publicación: 08/08/2016
• Nº Volúmenes: 1
• Idioma: Inglés