Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadicand inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment. Pancreatic Cancer brings to the forefront the most current advances that have been made in understanding pancreatic cancerdevelopment and successfully treating this dreadful disease. This volume provides information on the recent progress and improvements to date, including developments in molecular events, landmark clinical trials, the first mouse models, and targeted biologic therapies. INDICE: From the contents Series Preface.- Preface.- Section I: Molecular Pathology and Epidemiology.- Spectrum of human pancreatic neoplasia.- Molecular genetics of human pancreatic cancer.- Pancreatic intraepithelial neoplasia: Intraductal papillary mucinous neoplasia.- Familial Pancreatic Familial Chronic Pancreatitis and Pancreatic Cancer Risk.- Section II: Pancreatic Cancer Biology.- Pancreatic stem cells: injury and regeneration.- Pancreatic developmental biology.- Experimental systems for pancreatic cancer research.- Kras-based mouse models.- Cell signaling pathways in pancreatic cancer.- Pancreatic cancergenomics and proteomics.- Section III: Pancreatic Cancer Staging.- RadiologicStaging.- The Role of PET scanning in Pancreatic Cancer.- Endoscopic Ultrasound Staging.- Laparoscopic Staging.- Section IV: Surgery for Pancreatic Cancer.- Pancreaticoduodenectomy: Past to Present.- Total Pancreatectomy.- Distal Pancreatectomy.
- ISBN: 978-0-387-69250-0
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 425
- Fecha Publicación: 01/06/2008
- Nº Volúmenes: 1
- Idioma: Inglés