Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder. Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder Presents techniques and main findings in transcriptome research related to CNS synaptic function Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder Discusses current genetic findings, integrating tests for treatments leading to personalized treatments INDICE: 1. Biomarkers in Bipolar Disorder: Overview2. RNA and Micro-RNA Biomarkers in Bipolar Disorder3. Metabolomics in Bipolar Disorder4. Behavioral Models of Bipolar Disorder5. Structural Neuroimaging in Bipolar Disorder6. Neurochemical Imaging Findings in Bipolar Disorder7. Pharmacogenomics and Precision Psychiatry in Bipolar Disorder8. Translating Biomarkers from Bench to Bedside in Bipolar Disorder9. Genetic (GWAS) Biomarkers in Bipolar Disorders10. Mitochondrial Dysfunction in Bipolar Disorder11. Aging Mechanisms in Bipolar Disorder12. Staging and Neuroprogression in Bipolar Disorders13. Neuro-immune Pathways in Bipolar Disorder14. Glutamatergic Dysfunction in Bipolar Disorder15. Neurocognitive Endophenotypes and Biomarkers in Bipolar Disorder16. DNA Methylation in Bipolar Disorder17. Biomarkers of Lithium Efficacy in Bipolar Disorders18. Neuroendocrine Pathways in Bipolar Disorders19. Intracellular Signaling in Bipolar Disorder20. Circadian Rhythms and Bipolar Disorder21. DNA Damage and Repair Mechanisms in Bipolar Disorder22. Microbiome and Bipolar Disorder23. Bipolar Disorder and Plasticity: A Key Target for New Treatments24. Proteomic Approaches for Biomarker Discovery in Bipolar Disorder25. Drug Development in Bipolar Disorders: New Therapeutic Targets
- ISBN: 978-0-12-821398-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 528
- Fecha Publicación: 20/01/2022
- Nº Volúmenes: 1
- Idioma: Inglés