Cardiac aging, like aging in general, is a complex process involving numerouscellular and molecular changes, which along the way contribute to the expression of the multiple phenotypes of aging, ‘the different faces’ of cardiac aging. Several plausible theories have been considered to explain aging, e.g., evolution, free radical, somatic mutation, etc; and at this time it is most likely that these different theories are intertwined with each other without a definitive ‘winner’, reflecting a mixture of genetic and epigenetic elements foundin most aged individuals with cardiovascular defects. The demonstration in numerous animal models of the dramatic alterations in life-span achieved by geneengineering or dietary modifications, such as caloric restriction, further underscores the interplay of both genetic and environmental factors involved in aging, as well as acting through molecular and signaling pathways operative inthe heart and the vasculature. Includes 40 illustrations
- ISBN: 978-0-387-74071-3
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 500
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés