Skin Tissue Models for Regenerative Medicine

Skin Tissue Models for Regenerative Medicine provides a translational link for biomedical researchers across fields to aid in understanding of the inter-disciplinary approaches to skin regeneration. As the largest organ in the body skin is critical to survival, and engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo and psoriasis, to plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology, and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates in order to replace animal models. Offers preliminary description of normal structure/function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology, and emerging technologies (high throughput screening; additive manufacturing; stem cells; genetic engineering)Coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) extends to clinical requirements and skin diseases in vitro modelsAddresses legal requirements and ethical concerns in drugs and cosmetics in vitro testingEdited and authored by internationally renowned group of researchers, presenting the broadest coverage possible INDICE: Section 1 - Therapeutic Molecules and Cosmetics Testing 1.1 Pharmaceutical industry requirements 1.2 Cosmetic industry requirements 1.3 Animal experimentation 1.4 Emerging technologies Section 2 - Skin Diseases: clinical demands and diseased-skin in vitro models 2.1 Dermatology overall perspective: John McGrath, King's College London, UK 2.2 Skin Diseases/Disorders in vitro models 2.2.1 Melanoma 2.2.2 Genodermatoses 2.2.3 Psoriasis 2.2.4 Vitiligo Section 3 - Skin Substitutes: Clinical demands and skin tissue equivalents 3.1 Plastic Surgery overall perspective 3.2 Skin Tissue Equivalents 3.2.1 Strategies to improve Angiogenesis 3.2.2 Scarring-free approaches 3.2.3 Improving epidermal barrier Section 4 - In Vitro Models as study platforms of skin Biology 4.1 Hair follicle generation 4.2 Sweat glands formation 4.3 Skin Innervation 4.4 Control of skin Pigmentation 4.5 Inflammation 4.6 Hypodermis role 4.7 Induced Pluripotent Stem Cells Potential

• ISBN: 978-0-12-810545-0
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/11/2017
• Nº Volúmenes: 1
• Idioma: Inglés