Looking at Ribozymes: From Atomic to Molecular and Cellular Scales

Looking at Ribozymes: From Atomic to Molecular and Cellular Scales introduces ideas on how ribozymes work? through a comparison of their common features and specificities. How they work is not just a matter of enzymatic catalysis, but to a more granular level, how do the (macro) molecular organization at different scales make it possible, what function do they carry, where are they found, how did they evolve, and how have they been used? The book emphasizes common and specific features of natural and artificial ribozymes, from the basics, to more advanced aspects, making it ideal for undergraduates, grad students and researchers. Specific sections cover different areas of research, from the atomic scale (catalysis), to the molecular (folding, dynamics), macromolecular and cellular scales (dynamics, long-range interactions, self-assembly, cellular processes). The book is not a directory of ribozymes, instead providing comparative knowledge, including the inter-dependent relationships between the different scales of description based on different experimental and theoretical approaches. Provides a comparative knowledge of ribozymes based on scales of organization and descriptionCovers different areas of research, from the atomic scale (catalysis), to the molecular (folding, dynamics), macromolecular and cellular scalesIncludes the inter-dependent relationships between the different scales of description based on different experimental and theoretical approaches INDICE: Introduction. A small history of a ribozyme prototype (the hammerhead ribozyme)1. RNA: from non-enzymatic to enzymatic catalysis2. Catalytic diversity in ribozyme subclasses3. Folding, structure and dynamics of ribozymes4. Long-range interactions and macromolecular assemblies5. Molecular adaptation during evolution6. Ribozymes in Cellular Processes: from viroids to eukaryotes7. Natural and artificial ribozymes: evolution and design

• ISBN: 978-1-78548-210-6
• Editorial: ISTE Press - Elsevier
• Encuadernacion: Cartoné
• Páginas: 130
• Fecha Publicación: 01/10/2017
• Nº Volúmenes: 1
• Idioma: Inglés