Cholesterol Metabolism in Aging and Disease provides in-depth coverage on the mechanistic intersection between the aging process and cholesterol metabolism. The book covers the discovery of cholesterol, its biochemistry, and how it came to have such a prominent role in aging and disease. Important areas such as cholesterol biosynthesis and cellular cholesterol homeostasis are described in detail. Technological advancements in computational modeling are also discussed to help improve our understanding of cholesterol metabolism so that new therapeutic avenues are opened to help treat age-related diseases associated with the dysregulation of this key system. This is a must have reference for students and researchers interested in, or working in, various aspects of aging. In addition, it is ideal for clinician researchers and gerontologists. Offers detailed, yet accessible descriptions of the biochemistry of cholesterol metabolism and the changes that take place as we age Emphasizes the mechanistic changes to cholesterol metabolism which take place with age Discusses the importance of cholesterol metabolism and how disruptions to it underpin age-related diseases INDICE: 1. Introduction2. The role of Cholesterol in the Body3. The Cholesterol Biosynthesis Pathway4. Maintaining intracellular Cholesterol Homeostasis5. The regulation of whole body Cholesterol Metabolism6. How does aging impact Cholesterol Metabolism?7. Cholesterol metabolism and Cardiovascular Disease8. Cholesterol Metabolism and Cancer9. Cholesterol Metabolism and Alzheimer's Disease10. Cholesterol Metabolism in the Oldest old11. How Diet and Alcohol influences Cholesterol Metabolism12. Computational Models of Cholesterol metabolism
- ISBN: 978-0-12-822792-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 240
- Fecha Publicación: 01/11/2022
- Nº Volúmenes: 1
- Idioma: Inglés