CNS Cancer: models, markers, prognostic factors, targets, and therapeutic approaches

The volume will cover three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors. The volume will cover three areas of research in brain tumors INDICE: From the contents 1: PDGF-Based Malignant Glioma Model in Rats andMice. 2: Modeling Brain Tumors Using Avian Retroviral Gene Transfer. 3: UsingNeurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-GradeGliomas. 4: Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role p21-Ras in Glioblastoma Multiforme.- 5: Pten-Deficient Mouse Models for High-Grade Astrocytomas. 6: The NF1/p53 Knockout Transgenic Model for Malignant Glioma. 7: Conditional Models for Brain Tumors in Transgenic Mice. 8: Human Brain Tumor Cell and Tumor Tissue TransplantationModels. 9: Transformation of Human Brain Cells in Culture as Models for BrainTumors. 10: History of Important Carcinogen-Induced Brain Tumor Cell Lines. 11: Neuro-Oncogenesis Induced by Nitroso-Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition.

• ISBN: 978-1-60327-552-1
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 760
• Fecha Publicación: 01/05/2009
• Nº Volúmenes: 1
• Idioma: Inglés