The Cell Biology of Stem Cells discusses multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem celltrafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. It provides much of the current understanding of the cell biology of stem cells and discusses many of the open questions that remain to be answered. Describes the mechanisms that support early developmental decisions in the mouse pre?implantation embryo Addresses the structure and function of the three?dimensional space of the nucleus in ES cells Illustrates the dynamics and regulation of DNA replication in ES cells Addresses novel genome?wide approaches to analyze splicing and alternative splicing patterns at a global scale INDICE: Early Embryonic Cell Fate Decisions In The Mouse.- Nuclear Architecture In Stem Cells.- Epigenetic Regulation Of Pluripotency.- Autosomal Lyonization Of Replication Domains During Early Mammalian Development.- PreservationOf Genomic Integrity In Mouse Embryonic Stem Cells.- Transcriptional Regulation In Embryonic Stem Cells.- Alternative Splicing In Stem Cell Self?Renewal And Diferentiation.- MicroRNA Regulation Of Embryonic Stem Cell Self?Renewal AndDifferentiation.- Telomeres And Telomerase In Adult Stem Cells And Pluripotent Embryonic Stem Cells.- X Chromosome Inactivation And Embryonic Stem Cells.- Adult Stem Cells And Their Niches.- Adult Stem Cell Diferentiation And Trafficking And Their Implications In Disease.- Vertebrates That Regenerate As ModelsFor Guiding Stem Cells.- Reprogramming Of Somatic Cells To Pluripotency
- ISBN: 978-1-4419-7036-7
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 226
- Fecha Publicación: 28/09/2010
- Nº Volúmenes: 1
- Idioma: Inglés