Isocitrate Dehydrogenase Inhibitors in Cancer Chemotherapy presents an in-depth and up-to-date compilation of research on isocitrate dehydrogenase as drug target to be used as a sensitizing agent in chemotherapy. The book brings a combination of medicinal, biological and chemical points-of-view to fully cover the subject. It discusses topics such as IDH place in cellular metabolism, mutant IDH as drug target, mono- and poli-therapies based on IDH1/2 inhibitors, and IDH1/2 inhibitors in leukemia, gliomas and other brain tumors, and potential importance in gastrointestinal cancers. Additionally, it discusses isocitrate dehydrogenases as target for theranostics, therapeutic strategies and future perspectives.This is a valuable resource for cancer researchers, oncologists and members of the biomedical field who are interested to learn more about IDH inhibitors and their potential as sensitizing agents for chemotherapy. Presents comprehensive and up-to-date review of current trends in design IDH inhibitors and their use as adjuvant therapy Contains summarized tables and schematic diagrams in each chapter to give a clear overview of the recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field INDICE: 1. Isocitrate dehydrogenase and its place in cellular metabolism2. Wild type and mutant IDH as drug target3. Holy grail of combination therapy? Possibilities and limitations of mono- and poli-therapies based on IDH1/2 inhibitors4. Two faced IDH. The good and bad in prognosis5. Inhibitors of IDH1/2 in leukemias6. Inhibitors of IDH1/2 in gliomas and other brain tumors7. Potential importance of IDH in gastrointestinal cancers8. Isocitrate dehydrogenases as target for theranostics9. Resistance emerging and therapeutic strategies10. Challenges and future perspectives
- ISBN: 978-0-323-90197-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 200
- Fecha Publicación: 01/09/2022
- Nº Volúmenes: 1
- Idioma: Inglés