Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation brings together current opinion and research activities from Japan, the US, and Europe on the subject of genotoxic thresholds. In regulation, it is an adage that genotoxic carcinogens have no thresholds for action, and that they impose cancer risk on humans even at very low levels. This policy is frequently called into question as humans possess a number of defense mechanisms including detoxication, DNA repair, and apoptosis, meaning there is a threshold at which these genotoxic carcinogens take action. The book examines these potential thresholds, describing the potential cancer risks of daily low-level exposure, the mechanisms involved (such as DNA repair, detoxication, translesion DNA synthesis), chemical and statistical methods of analysis, and the ways in which these may be utilized to inform policy. Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation is an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation. Unites an international team of experts to provide a balanced overview of the current opinion on thresholds of genotoxic carcinogensProvides all the information readers need to determine a safe threshold for potential genotoxic carcinogensIncludes information on the mechanisms of genotoxic carcinogens and how these can inform regulationServes as an essential reference for any professional researchers in genetic toxicology and those involved in toxicological regulation INDICE: SECTION I: THRESHOLDS OF GENOTOXIC CARCINOGENS 1. Low dose effects of chemical carcinogens 2. Cancer risk at ultra-low dose 3. Non-linearity of tumor induction at low doses   4. Low dose effects of radiation and chemicals SECTION II: MECHANISMS OF GENOTOXIC THRESHOLDS 5. Role of translesion DNA synthesis in chemical mutagenesis and the thresholds 6. Thresholds of alkylating carcinogens including the case of Viracept 7. Role of DNA repair in oxidative carcinogenesis and the implication in thresholds 8. Thresholds for genotoxicity in germ cells 9. DNA damage induced by endogenous insult SECTION III: REGULATION OF LOW DOSE GENOTOXIC CARCINOGENS 10. Threshold of toxicological concern in pharmaceutical contaminants 11. Approach to threshold issues by ILSI 12. Consensus of IWGT for genotoxic thresholds 13. Practical thresholds in occupational exposure limits for carcinogens 14. Statistical analysis of genotoxic thresholds SECTION IV: INTERACTION OF GENOTOXIC CARCINOGENS IN COMPLEX ENVIRONMENTAL MIXTURES 15. Thresholds for genotoxicity of air pollutants 16. Phase II detoxication and the contribution to genotoxic thresholds 17. Thresholds in environmental carcinogens SECTION V: LOW-LEVEL EXPOSURE OF GENOTOXIC CARCINOGENS AND FOOD SAFETY 18. Safe doses of genotoxic compounds in food 19. Risk communication about genotoxic thresholds

• ISBN: 978-0-12-801663-3
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 256
• Fecha Publicación: 01/06/2016
• Nº Volúmenes: 1
• Idioma: Inglés