Clinical Bioenergetics: From Pathophysiology to Clinical Translation

Mitochondrial energy shortfall has long been considered an important agent across a range of clinical pathologies - from inherited disorders that affect energy metabolism to intoxications, cardiometabolic and neurodegenerative diseases. Bioenergetics - the study of the transformation of energy in living organisms- stands as a growing, innovative discipline tackling functional aspects of energy metabolism in biological processes and disease. Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides an in-depth view of recent developments in understanding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Early foundational chapters offer a strong basis in foundational aspects of bioenergetics and disease, including the omics landscape of impaired mitochondrial bioenergetics; and hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergeticsDiscusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disordersFeatures chapter contributions from international leaders in translational bioenergetics research and clinical practice INDICE: Part 1: Foundational Aspects of Bioenergetics and Disease 1. Bioenergetics in Clinical Medicine: An Overview 2. Tissue Specificity of Energy Metabolism in Mitochondria 3. Omics Landscape of Impaired Mitochondrial Bioenergetics 4. Sex Hormones, Tissue Bioenergetics and Metabolism in Humans Part 2: Disease-Specific Case Studies 5. Impaired Bioenergetics in Inherited Disorders: Clinical Features 6. Abnormal Energy Metabolism in Obesity and Insulin Resistance 7. Cardiac Energy Metabolism Impairment in Heart Failure 8. Impaired Mitochondrial Energy Metabolism in Neurodegenerative Diseases 9. Impaired Energy Metabolism in Cancer: Clinical Aspects 10. Mitochondrial Dysfunction and Kidney Disease 11. Mitochondrial Stress, Bioenergetics and Signaling in Chronic Liver Diseases 12. Decreased Bioenergetics in Traumatic Brain Injury 13. Impaired Cellular Bioenergetics and Chronic Fatigue Syndrome 14. Impaired Mitochondrial Bioenergetics in Psychiatric Disorders 15. Mitochondrial Dysfunction and Impaired Bioenergetics of Pulmonary Fibrosis 16. Clinical Effects of Chemical Exposures on Mitochondrial Bioenergetics Part 3: Modes of Analysis in Clinical Bioenergetics 17. Monitoring Mitochondrial Oxygenation in Clinical Environment 18. MioPlates: New Mitochondrial Function Assay Technology 19. Measurement of Mitochondrial Bioenergetics with XF Technology 20. Assessing Metabolic Flexibility and Mitochondrial Bioenergetics 21. Bioenergetic Health Index: Cell-Specific Biomarker of Clinical Bioenergetics 22. Evaluating Tissue Bioenergetics via Magnetic Resonace Spectroscopy 23. Mitochondrial Metabolic Flexibility Predicted by Computer Modelling Part 4: Theraputic Opportunities for Impaired Bioenergetics 24. Models for Target Effects of Drugs on Mitochondrial Bioenergetics 25. Mitochondrial Drug Delivery Systems for Macromolecules: Therapeutic Application for Clinical Bioenergetics 26. Dietary Interventions for Patients with Impaired Bioenergetics 27. Novel Nutraceuticals to Tackle Brain and Muscle Bioenergetics 28. Therapeutic Potential of Cardiolipin-Protective Compound to Restore Mitochondrial Bioenergetics 29. MitoNEET as a Novel Drug Target for Mitochondrial Dysfunction 30. Translation of Bioenergetics Therapies: Challenges From Bench to Bedside 31. New Therapeutics to Modulate Mitochondrial Energy Metabolism in Neurodegenerative Disorders 32. Targeting Impaired Bioenergetics in Heart Failure 33. Pharmacological Targeting of Mitochondria in Cancer Cells 35. Bioactive Foods and Exercise in the Modulation of Impaired Mitochondrial Function in Chronic Kidney Disease 36. Efficacy of Transcranial and Systemic Photobiomodulation for the Enhancement of Mitochondrial Metabolism in Depression 37. Impairments in Oxidative Glucose Metabolism in Epilepsy and Advanced Metabolic Treatments: an Overview

• ISBN: 978-0-12-819621-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 600
• Fecha Publicación: 01/11/2020
• Nº Volúmenes: 1
• Idioma: Inglés