Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases

Tryptamine Microbiota-Deregulated Aminoacyl-tRNA Biosynthesis: A Conceptual Evolution of the Role of Microbiota Tryptamine in Human Diseases provides a detailed investigation into tryptamine, its underlying mechanisms, and metabolism across multiple diseases. The book explores key concepts of tryptamine, its biosynthetic pathways, and its influence in disease, specifically focusing on the Alzheimer's disease-associated gut bacterial sequence (ADAS). Various neurodegenerative conditions are covered alongside cancer, diabetes, infections, and chromosomal aberrations. Additionally, a chapter on gut tryptamine in domestic and agricultural animals is included. The book closes with case studies involving FDG-PET imaging in the context of tryptamine-treated mouse models and Alzheimer's disease patients.This book elucidates the implications of the gut microbiota-mediated tryptamine metabolism for human health, sharing insights into disease etiology, mechanisms, testing, prevention, and treatment. It is an ideal reference for researchers across the biomedical sciences. Provides a detailed investigation into tryptamine and its role in human healthExplores the relationship between microbiome tryptamine metabolome and a range of diseases, including diabetes, cancer, Alzheimer's disease and Parkinson's diseaseConsiders the role of tryptamine in cell death and the impairment of genome activitiesPaves the way for advances in disease prevention and treatment pathways INDICE: 1. Introduction2. Human gut microbial metabolite tryptamine inducing neurodegeneration causes chromosome and genome instability3. Mutagenicity and genotoxicity of naturally occurring tryptamines and their principle metabolites4. Abundant urinary tryptamine as indicator of UTI and nosocomial infections5. Proteus mirabilis, diseases and tryptamine6. Microbial tryptophan metabolites in cancer and leishmaniasis7. The effect of human microbial metabolome on multisensory integration in aging and neurodegenerative diseases8. Retinitis Pigmentosa (RP): RP-causative gene mutations, RP-related gene mutations, mosaicism and gut microbiome9. The tRNA aminoacylation interference in diseases10. Tryptamine interfere with Cytochrome P45011. Discovery of ADAS and Caudoviricetes prophage markers in metagenomics of type 2 diabetes and associated medical conditions12. Tryptamine, ADAS and microbiome in Parkinson’s disease13. Gut microbial ADAS and tryptamine in domestic and agricultural animals14. Tryptamine, stem cell/progenitor protein biosynthesis and aminoacyl-tRNA biosynthesis15. Tryptamine metabolite indole-3-acetic acid (IAA) in neurodegenerative diseases and other conditions16. FDG-PET: tryptamine-treated mouse model and Alzheimer’s disease patients. Conceptual evolution of microbiota tryptamine role in human diseases 17. Epilepsy, tryptamine-induced seizures, malfunction of ion channels, electrolyte abnormalities and antibiotic resistance18. Conclusions

• ISBN: 978-0-443-28830-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 318
• Fecha Publicación: 06/06/2024
• Nº Volúmenes: 1
• Idioma: Inglés