Standardizing Pharmacology: Assays and Hormones, Discoveries in Pharmacology, Volume 2

Discoveries in Pharmacology: Volume 2: Standardizing Pharmacology: Assays and Hormones, Second Edition presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars on the insights provided by and importance of the chapter today, along with an updated bibliography on the subject, with contributions from a Nobel Prize winner and other pioneers in pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings together discussions on key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hökfelt and V.C. Jordan. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. It will also be of interest to those who are interested in the history of medicine. Contains primary-source documents currently unavailable Presents the science behind major pharmacological breakthroughs by those who discovered them Includes commentary contextualizing the importance of discoveries and related readings INDICE: Section I. Redirected traffic: the history of drugs affecting haemodynamics 1. The control of blood pressure Part 1 - The discovery of beta adrenoceptor blocking drugs Part 2 - Peripheral anti-hypertensives: ganglion and adrenergic neurone-blocking agents Section II. The discovery and application of hormones 2. The emergence of endocrinology 3. Sex hormones Part 1 - Androgens and anabolic steroids Part 2 - The biological history of the Pill Part 3 - The chemical history of the Pill Section III. Overcoming the body's defence system 4. Anti-inflammatory drugs Part 1 - The proliferation of non-steroidal anti-inflammatory drugs (NSATDS) Part 2 - The story of aspirin, H.O.J. Collier 5. The inhibition of allergic reactions Part I - Histamine receptor antagonists Part 2 - Asthma: a long and continuing story Section IV. Assays and the molecular basis of drug action 6. A probe for the fine structures of the body 7. Isolated smooth muscle in pharmacology Part 1 - The guts of the matter: contribution of studies on smooth muscle to discoveries in pharmacology Part 2 - Bioassay: a pharmacological endeavour 8. Making visible the invisible (Recollections of the first experiences with the histochemical fluorescence method for visualization of tissue monoamines) 9. Receptors in pharmacology Section V. History of chemotherapy 10. From dyes to drugs 11. The discovery of penicillin and cephalosporins 12. The antibiotic explosion

• ISBN: 978-0-323-85517-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 530
• Fecha Publicación: 01/04/2023
• Nº Volúmenes: 1
• Idioma: Inglés