Epigenetics in Psychiatry

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addictionRelates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteinCatalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery INDICE: IntroductionOutline of EpigeneticsHistory of Epigenetics in PsychiatryRole of Epigenetics in the Neural Stem Cell and NeuronRole of Epigenetics in the BrainEpigenetic Epidemiology of Psychiatric DisordersLaboratory Techniques in Psychiatric EpigeneticsLaboratory Models in Psychiatric Epigenetics DNA Methylation and Histone Changes in SchizophreniaNon-Coding RNAs and Major PsychosisEpigenetics and Bipolar DisorderEpigenetics and Major Depressive DisorderEpigenetics and SuicideEpigenetics of Anxiety Disorder and Post-Traumatic Stress DisorderEpigenetics and Cognitive DisordersEpigenetics and Mental RetardationEpigenetics of Pervasive Developmental Disorders and ADHDEpigenetics and Drug AddictionEpigenetic Effects of Currently-Used Psychotropic DrugsDrugs Affecting DNA Methylation in Psychiatric Disorders;Histone Deacetylase Inhibitors and Psychiatric DisordersThe Social Environment and Epigenetics in PsychiatryNutritional Influences on Epigenetics in PsychiatryTransgenerational Epigenetics and Psychiatric Disorders

• ISBN: 978-0-12-417114-5
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 608
• Fecha Publicación: 12/09/2014
• Nº Volúmenes: 1
• Idioma: Inglés