Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices. In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states. In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions. Provides topical coverage on accessory components that are known to be involved in PcG recruitment in Drosophila and their less understood role in mammalsIncludes dedicated sections on PRC1 complexes and PRC2 complexes for quick referenceFeatures the role of RNA molecules in different aspects of Polycomb proteins involvement in epigenetic regulation, beginning with the key role of the Xist RNA in recruiting and spreading PcG complexes on the inactive X chromosome INDICE: Section 1: PRC1 Complexes 1. Variant PRC1 complexes 2. RING heterodimer formation and enzymatic activity 3. PC chromodomain 4. Histone H2A ubiquitylating PRC1 complexes 5. CBX-containing complexes and their roles 6. PRC1 and DNA damage 7. Scm and related components 8. Polycomb interaction partners 9. Drosophila PREs and cooperative recruitment 10. Binding of PRC1 complexes to PREs 11. KDM2B-containing complexes and PRC1 recruitment to CpG islands Section 2: PRC2 Complexes 12. PRC2 structure 13. PRC2 structure and function 14. PRC2 function and feedbacks 15. PRC2 recruitment and transcription 16. Global PRC2 activities 17. Ezh2 activating mutations 18. Role of PRC2 and the memory of repression in C. elegans 19. Non-histone targets of Ezh2 20. Cytoplasmic shuttling of PRC2 and its role Section 3: Covalent modifications of PcG proteins 21. Post-translational modifications of PRC1 22. Phosphorylation of PRC2 components 23. Ph Glycosylationand PRC1 aggregation 24. SUMOylation of Pc 25. Role of ncRNA in Polycomb repression
- ISBN: 978-0-12-809737-3
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 376
- Fecha Publicación: 05/01/2017
- Nº Volúmenes: 1
- Idioma: Inglés