Chiral Analysis: Advances in Spectroscopy, Chromatography and Emerging Methods

Chiral Analysis serves as a resource for scientists interested in the general area of chirality and chiral analysis, in particular. It covers an important area of analytical chemistry of relevance to a wide variety of scientific professionals, including chemistry graduate students, analytical chemists, organic chemists, professionals in the pharmaceutical industry, and others with an interest in chirality and chiral analysis. This thoroughly revised second edition includes coverage of several new, important areas of chiral analysis that have emerged since the first edition. Three of the new methods provide higher sensitivity than can be realized with the current methods and are expected to become mainstream applications: cavity based methods offer vastly higher sensitivity than conventional polarimetric methods, microwave chiral detection provides unsurpassed sensitivity for identifying diastereomers, and rotating electric field method offers a competing new approach for the separation of enantiomers. The fourth method, Coulomb explosion imaging, represents significant advance in technology with potential for widespread growth. The fifth topic, chirality in extraterrestrial life, has not been discussed in any other book and is important for understanding the origin of life. Broad coverage - this is the only volume to cover both spectroscopic and separation methods in a single volumeUp-to-date and detailed review of the various techniques available, including five new techniques that have emerged since the first editionContributions from a range of leading experts in the field, now edited by award-winning chirality researcher Prasad Polavarapu INDICE: History 1. Historical Introduction to Chirality Chirality in Nature 2. Chiral Asymmetry in Nature 3. Chirality in Extraterrestrial Life Established Spectroscopic Methods, Advances and Analyses 4. Light Polarization Techniques and Phase-Sensitive Detection 5. Chiral Molecular Tools Powerful for the Preparation of Enantiopure Compounds and Unambiguous Determination of their Absolute Configurations 6. A Chiroptical Probe for Determination of Absolute Stereochemistry by CD Excitron Chirality Method 7. Vibrational Optical Activity in Chiral Analysis 8. Vibrational Raman Optical Activity 9. Complete Analysis of Chiroptical Spectra 10. Advances in Chiral Analysis by NMR Spectroscopy 11. Chiral Analysis in Mass Spectrometry: Applications of Chromatography and Ion Mobility 12. Chiral Analysis in Pharmaceutical Industry 13. Chiroptical Spectroscopy of Biofluids 14. Chiral Analysis of Nanoscale Objects 15. Regression Modeling of Chiroptical Spectra Chromatographic Methods 16. Chiral Analysis Using Gas Chromatography 17. Chiral Analysis Using HPLC 18. Chiral Analysis by Capillary Electromigration Techniques Novel Emerging Methods 19. Cavity-based Chiral Polarimetry 20. Chiral Analysis by High-Resolution Molecular Rotational Spectroscopy 21. Chiral Rotational Spectroscopy 22. Chiral Analysis Using Rotating Electric Fields 23. Coulomb Explosion Imaging of Chiral Molecules

• ISBN: 978-0-444-64027-7
• Editorial: Elsevier Science
• Encuadernacion: Rústica
• Páginas: 700
• Fecha Publicación: 01/04/2018
• Nº Volúmenes: 1
• Idioma: Inglés