Studying Ageing and Disease in Laboratory Mice: A Handbook

Studying Ageing and Disease in Laboratory Mice: A Handbook reviews mouse models commonly used in studies on ageing. The book highlights the advantages and disadvantages of different strategies and discusses their relevance to disease susceptibility. In addition to addressing the genetics and phenotypic analysis of mice, examples of models of delayed or accelerated ageing and their modulation by caloric restriction are discussed. With the focus on laboratory mice models, the book provides a toolbox of techniques which can be used to consistently assess their health span. Topics discussed include assessing ageing in rodents, available models, and experimental plans and protocols. This book is valuable resource for researchers, scientists and professionals, but will also be ideal for students and practitioners who wish to broaden their knowledge in the field. Provides a single source of information, with up-to-date reviews and examples of experimental plans Includes a toolbox of techniques that can be used to consistently assess the health span of laboratory mice Reviews the current state of knowledge, along with example protocols and personal experiences that may not make their way in to research manuscripts Gives a range of different approaches, allowing readers to make informed decisions INDICE: Part 1: Concepts in Ageing1. An overview of ageing in laboratory mice and man - Paul Potter + others2. Factors important in modelling ageingPart 2: Assessing Ageing in Rodents3. Lifespan and Healthspan - Paul Potter and Ilaria Bellantuono4. Phenotyping Ageing Laboratory Mice -Dan Ehninger5. Frailty Indices - Susan Howlett6. Resilience ChallengesPart 3: Available Models7. Inbred, wild type and other strains8. Progeroid Models -Sulev Koks9. Modifications affecting Ageing - Caloric restriction, drugs, - JR, Dan Ehninger10. Models of Multimorbidity11. Models of Ageing Disease - Paul Potter + OthersPart 4: Experimental Plans12. Breeding and maintaining cohorts - All13. Factors influencing ageing cohorts - Dan Ehninger14. Example protocols - All

• ISBN: 978-0-12-824018-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 316
• Fecha Publicación: 01/09/2022
• Nº Volúmenes: 1
• Idioma: Inglés