Brucella Melitensis: Identification and Characterization of Potential Drug Targets

Brucella melitensis is a bacteria widely characterized as a biological warfare pathogen. Systems biology and bioinformatics provide new methods and insights into Brucella pathogenesis, host-pathogen interactions, and for the rapid development of new potential drug targets. Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses in general, and B. militensis 16M in particular. The title first demonstrates the identification of putative genes as potential drug targets, employing a subtractive genomic approach. It  considers the virulent genes of this bacteria that negatively affect humans, and lists twelve potential virulence genes as drug targets. Secondly, the title considers the screening of potential drugs against the bacteria's virulence genes, through molecular modeling, computational screening, drug discovery and molecular docking studies. The book demonstrates in silico approaches that offer insight into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to identify drug targets, namely: Identifying and characterizing Vaccine targets for Brucella melitensis; in silico screening and identification of novel drug targets from the total Brucella melitensis proteome; computational modeling and evaluation of the best potential drug targets through comparative modeling; molecular docking and dynamics simulations of  novel drug targets and; in silico validation and ADMET analysis for best lead molecules. Researchers will find in this book a focused solution on using bioinformatic tools to find virulence targets. Covers the identification and characterization of vaccine targets for Brucella melitensisPresents in silico screening and identification of novel drug targetsGives computational modelling and evaluation for potential drug targets Offers molecular docking and dynamics simulations for novel drug targetsDetails in silico validation and ADMET analysis for best lead molecules INDICE: 1. Introduction to Brucellosis 2. Identification and characterization of vaccine targets for Brucella melitensis through in silico approaches 3. Computational modeling and evaluation of best potential drug targets through comparative modeling 4. Molecular docking and dynamics simulations of novel drug targets 5. In silico validation and ADMET analysis for best lead molecules 6. Summary and Conclusions

• ISBN: 978-0-323-85681-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 210
• Fecha Publicación: 01/05/2021
• Nº Volúmenes: 1
• Idioma: Inglés