Structural Biology in Immunology: Structure/Function of Novel Molecules of Immunologic Importance

Structural Biology in Immunology: Structure and Function of Novel Molecules of Immunologic Importance delivers important new information on structure and function relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, cancer, and inflammatory bowel disease has been dramatically altered. An improved appreciation of central structure function relationships will further enhance our ability to understand what defects in a normal individual can lead to disease. Furthermore, using this knowledge we can also better tailor more targeted and specific therapies, that will have increased efficacy with an improved side effect profile. These insights are currently applied for the development of enhanced antibodies, co-stimulatory molecules and multi-specific reagents. Describes novel/recently discovered immunomodulatory proteins, including antibodies, and co-stimulatory or co-inhibitory moleculesEmphasizes new biologic and small molecule drug design through the exploration of structure-function relationshipFeatures a collaborative editorial effort, involving clinical immunologists and structural biologistsProvides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunologyAllows students and others outside of the relevant field a bridge to learn about computer modelling and structure bases design principles INDICE: 1. Introduction: Structural elements of the immune response 2. Organization of the immunological synapse 3. T cell response and superagonists 4. Rational chemical biology based design of specific Ab 5. Computational aspects of antibody analysis 6. NK receptors 7. Receptor antibodies 8. Structural biology IgE 9. Structure guided antibody development 10. Promiscuity in the Ig and TNF/TNFR Superfamilies 11. Structure-function analysis in anti-DNA antibodies 12. Role of the constant region in antibody antigen interactions in the protective response

• ISBN: 978-0-12-803369-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 200
• Fecha Publicación: 01/01/2018
• Nº Volúmenes: 1
• Idioma: Inglés