Mechanisms of Disease Pathogenesis in Multiple Sclerosis

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book. Summarizes our current understanding of Multiple Sclerosis Discusses clinical features and available biomarker monitoring Focuses on mechanisms that drive disease pathogenesis INDICE: 1. Multiple Sclerosis. Clinical course, open questions, unmet clinical needs2. CNS Imaging in Multiple Sclerosis3. Biomarkers in Multiple Sclerosis4. Pre-clinical Models of Multiple Sclerosis5. iPSC Models to Study Multiple Sclerosis6. T cells in Multiple Sclerosis7. B cells in Multiple Sclerosis8. Antibodies in Multiple Sclerosis9. Microglia in Multiple Sclerosis10. Peripheral myeloid cells in Multiple Sclerosis11. Antigen Presenting Cells in Multiple Sclerosis12. Oligodendrocytes in Multiple Sclerosis13. Astrocytes in Multiple Sclerosis14. The Blood Brain Barrier in Multiple Sclerosis15. Brain Lymphatics in Multiple Sclerosis16. Mechanisms of Neurodegeneration in Multiple Sclerosis17. Microbiome in Multiple Sclerosis18. Genetics of Multiple Sclerosis19. Environmental Factors in Multiple Sclerosis20. Novel Therapies for Multiple Sclerosis

• ISBN: 978-0-12-823848-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/10/2022
• Nº Volúmenes: 1
• Idioma: Inglés