Autophagy and Cardiometabolic Diseases: From Molecules to Medicine

Autophagy and Cardiometabolic Diseases: From Molecular Mechanisms to Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. The processes within the science of autophagy are not described in isolation but in concert with other cellular and/or metabolic processes such as lipogenesis, glucose and energy metabolism as well as apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. It provides explanation and distinguishes the delicate role for autophagy in the pathogenesis and complications for cardiometabolic diseases.  By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies, and represents an excellent case for the translational bench to bedside research strategy that is developed into effective clinical strategies. Perfect for cardiology researchers, scientists, and medical practitioners, it will serve as an important resource for the understanding of autophagy signaling in basic research to clinical medicine. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseasesProvides knowledge from internationally recognized contributors in the field, covering the role of autophagy in various components of cardiometabolic diseasesIncorporates a translational approach, covering the basic cellular biology of autophagy, presenting the role of autophagy regulation for both pathogenesis and complication of cardiometabolic diseases, and discusses how these mechanisms can be targeted for therapeutic regimen for cardiometabolic diseasesContains access to a companion website with additional illustrations and cartoons depicting the salient features of book; highlights of each chapter; and clinical trial highlights on autophagy-modulating drugs INDICE: Section I. Cell biology of cardiometabolic syndrome and autophagy 1. Overview of cardiometabolic syndrome 2. Overview of autophagy and its molecular regulation 3. Interplay among oxidative stress, redox signaling, ER-stress, autophagy and protein ubiquitination 4. Selective autophagy for specific organelles 5. Experimental models of autophagy and measurement of autophagy 6. Role of autophagy in cardiac physiology and pathophysiology Section II. Autophagy and pathogenesis of cardiometabolic disease 7. Autophagy and diabetes mellitus 8. Autophagy and hypertension 9. Myocardial Insulin Signaling and Autophagy 10. Autophagy and obesity 11. Autophagy and dyslipidemia 12. Autophagy and stroke 13. Polycystic Ovary Syndrome and Cardiometabolic Disease 14. Autophagy and thrombosis, vascular inflammation 15. Autophagy and Proteostasis in Cardiac Aging 16. Autophagy and central nervous system Section III. Autophagy and complications of cardiometabolic disease 17. Autophagy and chronic liver disease 18. Autophagy in acute and chronic kidney disease 19. Autophagy and fetal programming 20. Autophagy, oxidative stress and redox regulation Section IV. Translational approach of autophagy 21. Therapeutic drug discovery targeting autophagy I 22. Autophagy: A new therapeutic target 23. Autophagy regulates control of intracellular energy stores 24. Autophagy and epigenetics 25. Autophagy, exercise and life style modification

• ISBN: 978-0-12-805253-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 224
• Fecha Publicación: 01/05/2018
• Nº Volúmenes: 1
• Idioma: Inglés