Rosenbergs Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition

Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease provides a comprehensive introduction and reference to the molecular and genetic foundations of the majority of neurologic and psychiatric disease. This is an essential reference for the general medical practitioner, a core reference for clinical neurologists, psychiatrists and associated clinical professionals and a general tutorial reference for the neuroscience and clinical neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. This new edition represents a major revision to insure consistent presentation and coverage within each chapter authored by an international line-up of leading research scientists and clinical practitioners. Previous editions have established this book as the leading tutorial reference on neurogenetics. With this new edition the three key markets, research scientists, clinicians and genetic counselors will all continue to benefit from the content. The research community will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations. And genetic counselors will find this a comprehensive tutorial reference on the latest advances in the science, with links to genetic testing for specific diseases. * Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease.* Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain.* Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations. INDICE: SECTION I. GENERAL CONCEPTS OF DISEASE AND INVESTIGATIONAL TOOLS Mendelian, Nonmendelian, Multigenic Inheritance, and Complex Traits; Repeat Expansion Disorders: General Concepts and Mechanisms of Disease; Genetically Engineered Models Relevant to Human Neuropsychiatric Disease; Gene Mapping to Gene Targeting: Application of Mouse Genetics to Human Disease; Human Genomics and Disease; Gene Therapy for Central Nervous System Disorders; Stem cell therapy; Genotype-Phenotype Correlations; Neuroimaging; Analytical biochemistry and metabolomics; Causation, association and other statistical tools; DNA sequencing and other methods of genomic analysis; Registries, sample repositories, ICD-9 and DSM-S; Ethics in Neurology, Psychiatry, and the Neurosciences; Genetic counseling in neurology and psychiatry SECTION II. NEUROLOGIC DISEASES Down Syndrome; Triplet Repeat Diseases: Overview; Prion Diseases; Mitochondrial Disorders: The Mitochondrial Genome;  Mitochondrial Disorders Due to Mutations in the Mitochondrial Genome; Mitochondrial Disorders Due to Mutations in the Nuclear Genome; Mitochondria in Neurodegenerative Disorders; Peroxisomal Disorders; Lysosomal Disorders: Gaucher Disease; The Niemann-Pick Diseases / The Gm2-Gangliosidoses; Metachromatic Leukodystrophy and Multiple Sulfatase Deficiency: Sulfatide Lipidosis; Krabbe Disease: Globoid Cell Leukodystrophy; The Mucopolysaccharidoses and the Mucolipidoses; Disorders of Glycoprotein Degradation: Sialidosis, Fucosidosis, Alpha-Mannosidosis, Beta-Beta-Galactosidase Deficiency: GMl Gangliosidosis, Morquio B Disease, and Galactosialidosis; Farber Disease: Acid Ceramidase Deficiency, Farber Lipogranulomatosis; Wolman Disease; Lysosomal Membrane Disorders: LAMP-2 Deficiency; Fabry Disease: Alpha Galactosidase A Deficiency; Schindler Disease: Deficient Alpha-N-Acetylgalacosaminidase Activity; Degenerative Disorders: Alzheimer's Disease; Parkinson's Disease; Frontotemporal Dementias; Other Movement Disorders; The Inherited Ataxias; Friedreich Ataxia; Ataxia-teleangiectasia; Hereditary Spastic Paraplegia; Vanishing White Matter Disease; Neuro-Oncology: Genes and neurological cancer; Neurofibromatoses; Glioblastoma; Epilepsy: The Genetic Epilepsies; Demyelinating Disease: Demyelinating Diseases; Neuropathies and Neuronopathies: Peripheral Neuropathies;  Spinal Muscular Atrophies; Pain disorders; Congenital Myasthenic Syndromes; Myopathies: Dystrophinopathies; Limb-Girdle Muscular Dystrophies; The Congenital Myopathies; The Distal Myopathies; Hereditary Inclusion-Body Myopathies; The Myotonic Dystrophies; Facioscapulohumeral Dystrophy; Other Ion Channel Disorders; Dermatologic and Brain Disorders: The Phakomatoses; Lipoprotein Disorders; Apolipoprotein E: Structure and Function in Lipid Metabolism and Neurobiology / Cerebrotendinous Xanthomatosis; Stroke: The genetics of stroke; Metabolic Disorders: Disorders of Lipid Metabolism; Glycogen Storage Diseases / Disorders of Galactose Metabolism; Inborn Errors of Amino Acid Metabolism; Disorders of the Urea Cycle; Disorders of Glucose Transport; Maple Syrup Urine Disease: Clinical and Biochemical Perspectives; Congenital Disorders of N-linked Glycosylation; Disorders of Glutathione Metabolism; Canavan Disease; Purines; Porphyrias; Metal Metabolism; Wilson Disease; Menkes Disease; Neurodegeneration with Brain Iron Accumulation; Vitamins: Genetic and Dietary Influences on Life Span; Vitamins: Cobalamin and Folate; Disorders of Biotin Metabolism SECTION III. PSYCHIATRIC DISEASE Psychiatric Diseases: Challenges in Psychiatric Genetics; Depression; Bipolar Disorder; Schizophrenia; Obsessive-Compulsive Disorder; Tourette's Syndrome; Genetic Bases of Addictive Behaviors; Autism   SECTION IV. A NEUROLOGIC AND PSYCHIATRIC GENE MAP A Neurologic and Psychiatric Gene Map

• ISBN: 978-0-12-410529-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 992
• Fecha Publicación: 13/12/2014
• Nº Volúmenes: 1
• Idioma: Inglés