The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge of how the in utero environment could be the most important environment in shaping later risk for various diseases or conversely promote the health of the offspring. This book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Importantly, the common thread of how in utero and postnatal environmental changes may lead to DOHaD effects is through various epigenetic changes. Informs how everyday choices a pregnant woman makes could impact her child's developmentTies together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)Includes a boxed-in area in each chapter for further references and resources to keep up with the fieldFeatures video interviews with the authors and other key leaders in the field INDICE: 1: Introduction to the Concept of Developmental Origins of Health and Disease (DOHaD) 2: Historical Perspective of DOHaD in Humans 3. Overview of the Periconceptional Period through Post-Implantational Embryonic Development and Critical Windows of Time4. Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various DOHaD Effects5. Introduction to Fetal Hormonal Development and Programming6. Parental Nutrition and DOHaD7. Example Environmental Chemicals and DOHaD8. Maternal Neurological Disorders, Stress, Trauma, and DOHaD9. Cardiovascular Disorders and DOHaD10. Reproductive Disorders and DOHaD (I)11. Reproductive Disorders and DOHaD (II)12. Immune Disorders and DOHaD (I)13. Immune Disorders and DOHaD (II)14. Neurobehavioral Disorders and DOHaD15. Metabolic Disorders and DOHaD16. Renal Disorders and DOHaD17. Cancer and DOHaD18. Gastrointestinal System and DOHaD19. How the Father Might Epigenetically Program the Risk for DOHaD Effects in His Offspring20. Linkage Between In Utero Environmental Changes and Premature Birth21. Sex Specific DOHaD Effects in Humans and Animal Models22. Transgenerational Propagation of In Utero/Postnatal Environmental Changes23. Overall Resilience and Ability of the Conceptus to Cope with In Utero Environmental Changes24. How DOHaD Effects Have and Should Continue to Guide Public Policy Decisions and Legal Decisions25. Monitoring and Reversing Harmful DOHaD Effects26. Overall Resources to Keep Up with the Rapidly Advancing DOHaD Field and Future Directions
- ISBN: 978-0-12-801383-0
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 496
- Fecha Publicación: 01/09/2015
- Nº Volúmenes: 1
- Idioma: Inglés