Porous silicon has a range of properties, making it ideal for drug delivery, cancer therapy, and tissue engineering. Porous Silicon for Biomedical Applications provides a comprehensive review of this emerging nanostructured and biodegradable biomaterial. Chapters in part one focus on the fundamentals and properties of porous silicon for biomedical applications, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein-modified porous silicon films, and biocompatibility of porous silicon. Part two discusses applications in bioimaging and sensing, and explores the optical properties of porous silicon materials; in vivo imaging assessment and radiolabelling of porous silicon; and nanoporous silicon biosensors for DNA sensing and for bacteria detection. Finally, part three highlights drug loading and characterization of porous silicon materials, tumor targeting and imaging, and porous silicon scaffolds for functional tissue engineering, stem cell growth, and osteodifferentiation. With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in the field. Comprehensive review of porous silicon focusing on the fabrication and properties of this emerging materialSpecifically discusses drug delivery and orthopedic applications of porous siliconAimed at materials researchers and scientists in the biomaterials industry - particularly those concerned with drug delivery and orthopedics INDICE: Contributor contact details Woodhead Publishing Series in Biomaterials Foreword Preface Dedication Part I: Fundamentals of porous silicon for biomedical applications 1. Porous silicon for medical use: from conception to clinical use Abstract: 1.1 Introduction 1.2 Biocompatibility of micromachined silicon 1.3 From concept to clinic 1.4 Producing useful physical forms of nanostructured silicon 1.5 Clinical manufacture 1.6 Clinical trials 1.7 Conclusions and future trends 1.8 Acknowledgements 1.9 References 2. Thermal stabilization of porous silicon for biomedical applications Abstract: 2.1 Introduction 2.2 Thermal oxidation 2.3 Thermal carbonization 2.4 Thermal nitridation and annealing 2.5 Conclusions and future trends 2.6 References 3. Thermal properties of nanoporous silicon materials Abstract: 3.1 Introduction 3.2 Thermal constants of porous silicon (PSi) 3.3 Thermo-acoustic effect 3.4 Applications 3.5 Conclusions and future trends 3.6 Acknowledgment 3.7 References 4. Photochemical and nonthermal chemical modification of porous silicon for biomedical applications Abstract: 4.1 Introduction 4.2 Hydrosilylation and controlled surface modification of Si 4.3 Photo-initiated reactions 4.4 Mechanism of photo-initiated reaction 4.5 Electrochemical grafting 4.6 Reactions initiated by other means 4.7 Conclusions and future trends 4.8 Acknowledgments 4.9 References 5. Modifying porous silicon with self-assembled monolayers for biomedical applications Abstract: 5.1 Introduction 5.2 Silane-based monolayers 5.3 Hydrosilylation of alkenes and alkynes 5.4 Building more complicated interfaces 5.5 Conclusions and future trends 5.6 References 6. Protein-modified porous silicon films for biomedical applications Abstract: 6.1 Introduction 6.2 Proteins on surfaces 6.3 Porous silicon monolayers and multilayers 6.4 Characterization methods 6.5 Protein-modified PSi 6.6 Conclusions and future trends 6.7 References 7. Biocompatibility of porous silicon for biomedical applications Abstract: 7.1 Introduction 7.2 Assessment methods for testing the biocompatibility of biomaterials 7.3 Effects of the PSi-based material interactions at the cellular level 7.4 In vivo behaviour of PSi-based materials 7.5 Conclusions and future trends 7.6 Acknowledgements 7.7 References Part II: Porous silicon for bioimaging and biosensing applications 8. Optical properties of porous silicon materials for biomedical applications Abstract: 8.1 Introduction 8.2 Morphology of PSi 8.3 Effective medium models 8.4 Optical constants of nano-PSi 8.5 Stability of the optical properties of nano-PSi 8.6 Multilayer structures 8.7 Optical applications of PSi optical filters 8.8 Conclusions and future trends 8.9 References 9. In vivo imaging assessment of porous silicon Abstract: 9.1 Introduction 9.2 Magnetic resonance imaging (MRI) 9.3 Nuclear imaging 9.4 Optical imaging 9.5 Compiling PSi-based systems for imaging 9.6 In vivo imaging studies with PSi particles 9.7 Conclusions and future trends 9.8 Acknowledgments 9.9 References 10. Radiolabeled porous silicon for bioimaging applications Abstract: 10.1 Introduction 10.2 Methods for tracing drug delivery 10.3 Nuclear imaging in drug development 10.4 Radiolabeled PSi nanomaterials 10.5 Conclusions and future trends 10.6 References 11. Desorption/ionization on porous silicon (DIOS) for metabolite imaging Abstract: 11.1 Introduction 11.2 Substrate preparation for DIOS 11.3 Desorption and ionization mechanism of DIOS 11.4 Improved ionization methods based on DIOS 11.5 DIOS in mass spectrometry imaging (MSI) 11.6 Conclusions and future trends 11.7 References 12. Porous silicon for bacteria detection Abstract: 12.1 Introduction 12.2 'Indirect' bacteria detection 12.3 'Direct' bacteria detection 12.4 Conclusions and future trends 12.5 References 13. Nanoporous silicon biosensors for DNA sensing Abstract: 13.1 Introduction 13.2 Porous silicon (PSi) sensor preparation 13.3 PSi DNA sensor structures, measurement techniques, and sensitivity 13.4 Optical transduction 13.5 Electrical and electrochemical transduction 13.6 Corrosion of PSi DNA sensors 13.7 Effect of pore size on DNA infiltration and detection 13.8 Control of DNA surface density in nanoscale pores 13.9 Kinetics for real-time sensing 13.10 Conclusions and future trends 13.11 Acknowledgement 13.12 References Part III: Porous silicon for drug delivery, cancer therapy and tissue engineering applications 14. Drug loading and characterization of porous silicon materials Abstract: 14.1 Introduction 14.2 Methods for the loading of the cargo molecules into PSi pores 14.3 Characterization of drug-loaded PSi materials 14.4 Conclusions and future trends 14.5 References 15. Nanoporous silicon to enhance drug solubility Abstract: 15.1 Introduction 15.2 Loading poorly soluble drugs into PSi 15.3 In vitro studies of drug dissolution 15.4 In vivo studies of drug delivery 15.5 Conclusions and future trends 15.6 References 16. Multistage porous silicon for cancer therapy Abstract: 16.1 Introduction 16.2 The biology of cancer 16.3 Current therapeutics 16.4 Mesoporous silicon and therapeutic applications 16.5 Conclusions and future trends 16.6 References 17. Porous silicon for tumour targeting and imaging Abstract: 17.1 Introduction 17.2 Tumour targeting and imaging 17.3 Preparation of PSi particles 17.4 PSi particles for in vivo tumour targeting 17.5 PSi particles for in vivo tumour imaging 17.6 Conclusions and future trends 17.7 References 18. Porous silicon-polymer composites for cell culture and tissue engineering applications Abstract: 18.1 Introduction 18.2 Fundamentals of porous silicon (PSi) and PSi/polymer composite fabrication and functionalization 18.3 PSi/polymer composites 18.4 Polymers for tissue engineering 18.5 The grafting of biopolymers to PSi 18.6 PSi and tissue engineering 18.7 Applications of PSi-polymer composites in tissue culture and bioengineering 18.8 Conclusions and future trends 18.9 Sources of further information and advice 18.10 Acknowledgement 18.11 References 19. Porous silicon and related composites as functional tissue engineering scaffolds Abstract: 19.1 Introduction 19.2 Role of porous silicon (PSi) biodegradability 19.3 Strategies for PSi/polymer composite formulation 19.4 Studies related to orthopedic tissue engineering 19.5 Conclusions and future trends 19.6 References 20. Porous silicon scaffolds for stem cells growth and osteodifferentiation Abstract: 20.1 Introduction 20.2 Stem cells for bone tissue engineering: adult, neonatal and embryonic stem cells (ESCs) 20.3 Stem cells osteogenic differentiation and bone formation 20.4 Influence of pore size, nanoroughness and chemical surface treatment 20.5 Growth factors delivery and Si effects on osteodifferentiation 20.6 Conclusions and future trends 20.7 References Index
- ISBN: 978-0-08-101409-7
- Editorial: Woodhead Publishing
- Encuadernacion: Rústica
- Páginas: 572
- Fecha Publicación: 30/06/2016
- Nº Volúmenes: 1
- Idioma: Inglés