Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies. Provides an overview of the methodologies for biological target identification and ligand screeningIncludes case studies showing the development of functionalized nanomaterials and their biomedical applicationsHighlights the importance of functionalized nanomaterials for drug delivery, diagnostics and regenerative medicine applications INDICE: Introduction: From the magic bullet to advanced nanomaterials: An historical perspective Part I. Ligand selection and functionalization of nanomaterials 1. Phage display technology for screening antibody fragments 2. Bioengineered approaches for site-orientation of peptide-based ligands of nanomaterials 3. Engineered protein variants for bioconjugation 4. Engineering of nanozymes for biomedical applications 5. Strategies for the functionalization of mesoporous nanomaterials for biomedical use 6. Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer selection 7. Biological methodologies for assessment of functionality of nanomaterials Part II. Specific applications of functionalized nanomaterials in therapy and diagnostics 8. Functionalized graphene-based materials for bioimaging applications 9. Multifunctional magnetic nanoparticles for theranostic applications 10. Stimuli-sensitive grafting polymers for targeted anticancer drug delivery 11. Functional moieties for intracellular traffic of nanomaterials 12. Biofunctionalized mesoporous silica nanomaterials for nuclei targeting 13. Lipid-derived nanoparticles for targeted delivery of siRNA 14. Aptamer-siRNA nanoparticles for targeted anti-HIV therapeutics 15. Peptide and protein self-assembled nanofibers for vaccine development and immunotherapy 16. Functional biomaterials for vascular tissue engineering 17. Functionalized hydrogels for culture and delivery of cells Part III. Manufacturing, regulatory challenges and clinical testing of functionalized nanomaterial-based products 18. Manufacturing and safety guidelines for the manufactured functional nanomaterials 19. Challenges for planning clinical trials of functionalized nanomaterials 20. Clinical testing of ACCURINS® therapeutics: challenges and lessons learned

• ISBN: 978-0-323-50878-0
• Editorial: William Andrew
• Encuadernacion: Rústica
• Páginas: 616
• Fecha Publicación: 01/02/2018
• Nº Volúmenes: 1
• Idioma: Inglés