Protein Misfolding and Neurodegenerative Diseases: Disease-Modifying Targets and Drugs

Aimed at drug discoverers - i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Neurodegenerative Diseases: Molecular Targets and Disease-Modifying Compounds will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. . Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases. Provides a drug discovery? application oriented perspective, evaluating targets and candidates for their overall therapeutic potential. Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development. Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area. Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets INDICE: 1. Protein Quality Control and Tau: The Main Players, or the Usual Suspects?2. Protein Quality Control (PQC): The Neuronal Salvation Army3. Proteasomal degradation of mis-folded proteins: throwing out the bath water, but where's the baby?4. Unselective Disposal of Cellular Aggregates: Engulf, Devour and Digest to Recycle 5. Selective Disposal of Insoluble Protein Aggregates: Pick, Transport and Remove to Cure 6. Rescuing Insoluble Protein Aggregates: Friends or Foes?

• ISBN: 978-0-12-800186-8
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 15/03/2015
• Nº Volúmenes: 1
• Idioma: Inglés