Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread emphasizing how this information can be used to devise new modes of treatment of cancer, especially to combat the secondary spread. The important routes of approach are identifying the foci in the deregulated or in appropriately activated cascades of genetic signal transduction systems that might be amenable to targeted intervention. The book addresses the basic concepts relating to cancer biology and the genetic determinants and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development into the design of novel therapies that could lead to the identification, planning and definition of clinical trials. This book is the only unique volume with coverage of topics with defined aim at targeted therapy and it is a valuable source for cancer researchers, molecular oncologists and several members of biomedical field who are interested in knowing more about molecular approaches to the cancer therapy. Covers all the relevant topics with defined aim at targeted therapyEncompasses the basic aspects of cancer invasion and metastasisDiscusses signalling systems operating in normal cells and their deregulation in cancer cellsDirects attention to the foci in signalling systems that can be targeted with new and conventional drug-based approach INDICE: 1. Modulation of growth factor signaling in targeted therapy: Role the epidermal growth factor family and their receptors 2. The TGF-B family accessory type III receptor function in cancer progression 3. Insulin-like growth factor signaling as a target to control tumor progression 4. Angiogenesis in neoplasia and antiangiogenesis strategy in the control of tumor growth and metastasis 5. On the trail of TRAIL in tumor growth and angiogenesis 6. Hedgehog (Hh) signaling in EMT, CSCs and angiogenesis 7. Hedgehog is involved in angiogenic signaling by angiopoietin-1 8. Hippo signaling in cell proliferation, migration and angiogenesis 9. Tumor suppression and inhibition of angiogenesis by TXNIP 10. Suramin and polysulphonated naphthylureas as angiogenesis inhibitors 11. Quercetin inhibits growth factor signaling: suppresses angiogenesis and cell migration in vitro 12. Selenoproteins in cancer control 13. Inhibitor of DNA binding proteins in angiogenesis 14. Are there gains to be made in exploring anthrax lethal toxin (LeTx) as a tumor and an angiogenesis inhibitor? 15. Small molecule inhibitors of angiogenesis and cell proliferation 16. Control of tumor growth and angiogenesis by thalidomide and its analogues 17. Endogenous inhibitors of angiogenesis 18. Metformin and its antitumor attributes 19. Statins in cancer biology 20. The HMG (High mobility group) proteins in cancer progression 21. MTAs in EMT activation and tumor and metastasis promotion 22. S100A4 has potential benefits as a therapeutic target 23. Notch Signaling in carcinogenesis 24. Canonical and non-canonical activation of NF-?B in tumorigenesis 25. Stem cells in cancer therapy 26. Notable approaches to cancer immunotherapy
- ISBN: 978-0-12-812896-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 332
- Fecha Publicación: 03/07/2017
- Nº Volúmenes: 1
- Idioma: Inglés