Introduction to Nuclear Mechanics and Genome Regulation presents the first text to thoroughly explore the foundations of this exciting topic area, providing a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, the book serves as a invaluable reference for students, researchers, and clinicians looking to understand this area of cutting-edge study. Offers a thorough discussion of the biophysical principles underlying nuclear organization Contains applied case studies and full color images that support concept illustration, making this an invaluable reference for students, researchers and clinicians Features a diverse range of chapters covering the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNAIntroduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures INDICE: 1. Physico-chemical constraints in DNA2. 3D organization of chromosomes and functional gene clusters3. Spatial dimension to DNA transcription, replication, damage and repair4. Dynamics within the nucleus and functional microrheology5. Cytoskeleton to nuclear links and prestressed nuclear architecture6. Nuclear mechanotransduction and genetic networks7. Chromatin plasticity during differentiation, development and reprogramming8. Mechanical homeostasis of the nucleus during cell division and migration9. Nuclear mechanics in diseases and as diagnostic markers10. Evolutionary constraints in DNA packing and genome regulation
- ISBN: 978-0-12-812345-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 200
- Fecha Publicación: 01/11/2017
- Nº Volúmenes: 1
- Idioma: Inglés