INDICE: Preface. List of Contributors. 1 The Microenvironment in Cancer (Nicole N. Parker and Dietmar W. Siemann). 1.1 Introduction. 1.2 A highly selective process is required to obtain the cancer phenotype. 1.3 The cancer phenotype. 1.4 The extracellular matrix. 1.5 Motility, invasion, and metastatic ability. 1.6 Impact of the tumor microenvironment on the control of cancer. 1.7 Targeting the tumor microenvironment. 1.8 Summary. 2 Establishing the Tumor Microenvironment (Allison S. Betof and Mark W. Dewhirst). 2.1 Introduction. 2.2 Fromcancerous cells to a tumor. 2.3 A tumor is more than cancer cells and fibroblasts. 2.4 Communication between the tumor cells and stroma. 2.5 Hypoxia and angiogenesis. 2.6 Conclusion. 3 Contributions of the Extracellular Matrix to Tumorigenesis (Marie Schluterman Burdine and Rolf A. Brekken). 3.2 Manipulation of the ECM during tumor development. 3.3 Matricellular proteins and their complex effects on tumor development. 3.4 Conclusion. 4 Matrix Metalloproteinases and Their Inhibitors Friend or Foe (Mumtaz V. Rojiani, Marzenna Wiranowska and Amyn M. Rojiani). 4.1 Introduction. 4.2 Matrix metalloproteinases. 4.3 Tissue inhibitors of matrix metalloproteinases. 4.4 Concluding comments. 5 Role of Tumor-Associated Macrophages (TAM) in Cancer Related Inflammation (Antonio Sica and Chiara Porta). 5.1 Introduction. 5.2 Functional plasticity of macrophages.5.3 Macrophages as key orchestrators of cancer-related inflammation. 5.4 Recruitment and differentiation of TAM. 5.5 Protumoral functions of TAM. 5.6 Molecular determinants of TAM functions. 5.7 Therapeutic targeting of TAM. 5.8 Conclusions. 6 Bone Marrow Stroma and the Leukemic Microenvironment (William B. Slayton and Zhongbo Hu). 6.1 Introduction. 6.2 Components and function of the normal bone marrow microenvironment. 6.3 Leukemia and its microenvironment. 6.4 Summary. 7 Microenvironment Factors Influencing Skeletal Metastases (Alessandro Fatatis, Julia A. D'Ambrosio, Whitney L. Jamieson, Danielle L. Jernigan and Mike R. Russell). 7.1 Introduction. 7.2 The bone microenvironment as a target for cancer cell dissemination. 7.3 Roles of the bone microenvironment in promoting the arrest of circulating cancer cells at the skeleton. 7.4 Concluding remarks. 8 Premetastatic Niches (Kevin L. Bennewith, Janine T. Erler and Amato J. Giaccia). 8.1 Introduction. 8.2 Seeds influencing the 'Soil'. 8.3 Cellular components of premetastatic niches. 8.4 ECM components of premetastatic niches.8.5 Premetastatic niche formation precedes metastatic growth. 8.6 Therapeutictargeting of the premetastatic niche. 8.7 Evidence for premetastatic niches in the clinic. 8.8 Concluding remarks. 9 Hypoxia, Anerobic Metabolism, and Interstitial Hypertension (Michael F. Milosevic). 9.1 Introduction. 9.2 Pathophysiology of the tumor microenvironment. 9.3 Evaluating the tumor microenvironment. 9.4
- ISBN: 978-0-470-74996-8
- Editorial: John Wiley & Sons
- Encuadernacion: Cartoné
- Páginas: 454
- Fecha Publicación: 22/10/2010
- Nº Volúmenes: 1
- Idioma: Inglés