Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow.The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues. Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers INDICE: SECTION I. Clinical manifestations and disease detection1. Primary prevention of colorectal cancer2. Population-based universal screening for CRC. Secondary prevention3. The role of primary care in early referral of CRC patients4. Fast patient referral with suspected CRCSECTION II. Diagnosis and staging5. Endoscopic diagnosis of colorectal cancer6. Colon endoscopic capsule7. Endoscopic ultrasound in colorectal cancer8. Virtual colonoscopy. Colo-CT9. Colorectal cancer staging: ultrasound and multislice CT10. Applications of [18F] FDG PET and PET-CT in colorectal carcinoma11. MRI of rectal adenocarcinoma12. Molecular pathology of colorectal carcinoma13. Anatomopathologic diagnosis of CRC14. Colonoscopy. Technique and quality factors15. Endoscopic diagnosis of preneoplastic and neoplastic lesionsSECTION III. Treatment16. Multidisciplinary committee for a comprehensive approach to colorectal cancer patients Endoscopic treatment17. Endoscopic treatment of preneoplastic or early lesions18. Endoscopic monitoring19. Advanced endoscopy in CRC. Colorectal prostheses Surgical treatment20.? Surgical Emergency in RCC21.? Experimental surgery in RCC22. Colon and rectal cancer surgery23. Treatment of liver metastases in colorectal cancer Pharmacological treatment and radiotherapy24. Chemotherapy in advanced and metastatic disease25. Adjuvant chemotherapy in colorectal cancer26. Oral administration of cytostatic drugs for colorectal cancer treatment27. Complementary and intraoperative neoadjuvant chemotherapy in rectal cancer28. Immunology and immunotherapy in colorectal cancer Anesthetic and postoperative management29. Multimodal rehabilitation: optimizing pre and intraoperative surgery in colorectal cancer30. Postoperative management: Complications and critical care unit management31. Pain units: Symptom controlSECTION IV. Molecular and biological mechanisms of CRC32. The role of intestinal microbiota in the colorectal cancer33. Genetic susceptibility to colorectal cancer and chemotherapy response34. Stem cells and colon cancer35. Signaling pathways in colon cancer36. Colorrectal Cancer a Darwinian the Celular Inmune-Selection Model37. Epithelial-mesenchymal transition and colorectal cancerSECTION V. New diagnostic methods38. Biomarkers39. Bioinformatic tools for research in colorectal cancer40. Omic-based Biomarkers for Colorectal CancerSECTION VI. Biobanks41. Regulations regarding the use of human biological samples for research42. The role of biobanks in the study of colorectal carcinoma SECTION VII. Epidemiological studies in CRC43. Incidence and mortality of colorectal cancer : an international and regional vision44. Prognosis and follow-up of colorectal cancer patients. Role of diagnostic and therapeutic delaySECTION VIII. Hereditary colorectal cancer45. Hereditary nonpolyposis colorectal cancer46. Hereditary polyposis colorectal cancerSECTION IX. Addressing the consequences of CRC47. Addressing and psychologically controlling the disease48. Ostomy care49. Fecal incontinence and colorectal cancer50. Ethical issues in CRC diagnosis and treatment51. Sexuality in Ostomized Digestive Patients (Sexual Dysfunction in the Ostomized Patient)
- ISBN: 978-0-323-90055-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 670
- Fecha Publicación: 28/10/2021
- Nº Volúmenes: 1
- Idioma: Inglés