Bioenvironmental Issues Affecting Mens Reproductive and Sexual Health

Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into sections designed to enable a logical flow of knowledge. The book begins by looking at the development and embryology of key organs involved in male reproduction and their structural anatomy and current physiology. Next, the regulatory requirements to evaluate reproductive toxicity, with a particular emphasis on clinical aspects, are explored. Finally, the book presents the details of specific environmental agents that affect male reproduction and men's health. Individual chapters within the book range from basic to translational, but all hold clinical relevance, bringing an essential reference to those working and learning in the field of reproductive toxicology and men's reproductive health. Brings together the leading authorities on male reproduction, sexual health and how the environment affects these issuesProvides guidelines and reference values of various reproductive hormones, semen parameters and inclusion/exclusion criteria for clinical trialsDescribes the most efficient methods by which to design protocols for sperm safety studies and reproductive toxicology research INDICE: Section  I: 1. Testis 2. Epididymis 3. Seminal Vesicles 4. Prostate 5. Penis Section II: 6. Components of hypothalamic-pituitary-gonadal (HPG) axis and endocrine  regulation 7. Components  of erection and ejaculation 8. Components  of steroidogenesis, spermatogenesis, sperm maturation Section III: 9. EPA and OECD perspectives on reproductive and developmental toxicity testing 10. FDA and ICH guidelines on reproductive and developmental toxicity testing 11. Reproductive study evolution and protocol development guidelines 12. IND submissions and issues with multicenter sperm safety clinical trials Section IV: 13. Male reproductive toxicants and possible mechanism(s) of action 14. Endocrine disruptors and their role in reproductive development and male infertility 15. Role of oxidative stress and reproductive toxicity 16. Role of genomics, proteomics, and metabolomics in male reproduction 17. Endocrine disruptors and male sexual dysfunction 18. Environmental issues resulting in hypogonadism, i.e., andropause? Section V: 19. Role of risk factors such as smoking, alcohol abuse, and obesity in male reproduction 20. Specific environmental toxicants, e.g., PCBs, DDT, etc. on male reproduction 21. Drugs, environment, and chemical exposure in the realm of sexuality 22.  Epidemiology of male reproductive issues 23.  Epidemiology of male sexual dysfunction 24. Aphrodisiacs and 'over-the-counter' recreational agents, 'body building' anabolic steroids, counterfeit products and growth hormone and their effect on male reproduction   Section VI: 25. Standardized semen evaluation and quality control management 26. Standard operating procedure (SOP) on penile duplex Doppler evaluation 27. Environmental issues and how they may affect evaluations 28. Role of environment on gene regulation and stem cells 29. Environmental and socio-economic factors affecting men's health 30. Future directions for research

• ISBN: 978-0-12-801299-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 624
• Fecha Publicación: 01/09/2017
• Nº Volúmenes: 1
• Idioma: Inglés