New approach for drug repurposing represents drug discovery and development which is a tedious process that requires 10-15 years of time, investments up to $1-2 billion, and have high risk of failure to enter into market for clinical applications. As the drugs has to pass through number of developmental phase, the likelihood for a drug to be approved from phase I clinical trial to United States of Food and Drug Administration (USFDA) approval is less than 10%. More than 90% of drugs failed in due to toxicity, efficacy and clinical trials. Drug repurposing is one of the roadway to accelerating drug discovery and development for treating disease and thus to providing better quality of life. This volume covers an overview of drug repurposing, novel methods, mechanism of action, lab on chip for drug repurposing, computational biology, system biology, artificial intelligence and machine learning for drug repurposing, target identification, target mining, high throughput drug screening, clinical trial of repurposed drug, repurposed biologics, and regulatory consideration and intellectual property right of repurposed drug. This volume highlights a number of aspects of the drug repurposing that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest. To offer drug repurposing, novel methods, mechanism of action, lab on chip for drug repurposing,To offer computational biology, system biology, artificial intelligence and machine learning for drug repurposing,To offer high throughput drug screening, clinical trial of repurposed drug, repurposed biologics, and regulatory consideration INDICE: PrefaceVijai Singh1. An introduction to drug repurposingVijai Singh2. New approaches for drug repurposingGovinda Raj and Deepak Balaji Thimiri Govindaraj3. Reimagining old drugs with new Tricks:Mechanism, strategies and notable success in drug repurposing for neurological disordersPravir Kumar, Samuel Raj, Rashmi K. Ambasta, Neetu Rani, Aastha Kaushik, Shefali Kardam and Sonika Kag4. Lab-on-chip for testing of repurposed drugAlok Pandya5. Computational biology approaches for drug repurposingMustafeez Mujtaba Babar6. Synergizing Drug Repurposing and Target Identification for Neurodegenerative DiseasesPravir Kumar, Mehar Sahu, Shrutikeri Vashishtha, Neha Kukreti, Ashima Gulia, Aashish Russell and Rashmi K. Ambasta7. Artificial Intelligence and ML for drug repurposingAnil G. Jegga and Sudhir Ghandikota8. Genomic approaches for drug repurposingVijai Singh9. Systems biology approaches for drug repurposingAjay Kumar I10. High-throughput screening for drug repurposingSunday N. Okafor, Eze Chinecherem and Ahuchaogu Ikenna11. Approaches of pre-clinical and clinical trials of repurposed drugAjay Kumar I12. Repurposing of biologics and biopharmaceuticalsAjay Kumar I13. Innovative Target Mining Stratagems to Navigate Drug Repurposing EndeavoursSaraswathy Ganesan Rajalekshmi14. Regulatory considerations and intellectual property right of repurposed drugMustafeez Mujtaba Babar
- ISBN: 978-0-443-22338-9
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 406
- Fecha Publicación: 22/05/2024
- Nº Volúmenes: 1
- Idioma: Inglés