Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment ofpsychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulatingglutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The abilityto treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book. Contemporary monograph on glutamate-based approaches to treat psychiatric drugs The approaches described in this text exploit both metabotropicand ionotropic glutamate receptors Focus on translational research, with manyof the authors coming from industry All are acknowledged authorities in the glutamate field INDICE: Darryle D. Schoepp, Phil Skolnick: Introduction.- Phil Skolnick, Piotr Popik, and Ramon Trullas: N-Methyl-D-Aspartate (NMDA) Antagonists for theTreatment of Depression.- Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc, Gabriel Nowak: Ionic glutamate modulators in depression (zinc, magnesium).- Eric S. Nisenbaum and Jeffrey M. Witkin: Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy.- Jeffrey M. Witkin: Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors.- Gary Lynch Julie C. Lauterborn, Christine M. Gall: Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders.- Douglas J. Sheffler and P. Jeffrey Conn: Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia.- Hisashi Ohta, Hiroshi Kawamoto and Gentaroh Suzuki: mGluR1 Negative Allosteric Modulators: an Alternative Metabotropic Approach for the Treatment of Schizophrenia.- Svetlana Semenova and Athina Markou: Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence.- Joanna M. Wieronska, Gabriel Nowak, Andrzej Pilc: Metabotropic Approaches to Anxiety.
- ISBN: 978-3-0346-0240-2
- Editorial: Birkhaüser
- Encuadernacion: Cartoné
- Páginas: 250
- Fecha Publicación: 01/09/2010
- Nº Volúmenes: 1
- Idioma: Inglés