For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers. Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy INDICE: Vertical pathway targeting in cancer therapyHistone Deacetylases (HDACs) as Mediators of Resistance to Apoptosis in Melanoma and as Targets for Combination Therapy with Selective BRAF InhibitorsTargeting the tumor stroma as a novel treatment strategy for breast cancer - shifting from the neoplastic cell-centric to a stroma-centric paradigmTargeting the Metabolic Microenvironment of TumorsTargeted Therapy for MatastasisEmerging Strategies for Targeting Cell Adhesion in Multiple MyelomTargeting Notch Signaling for Cancer Therapeutic InterventionStem-like cells and therapy resistance in squamous cell carcinomasTargeting the tumor stroma as a novel therapeutic approach for prostate cancerResistance to chemotherapy: short-term drug tolerance and stem cell-like subpopulationsIntratumoral Heterogeneity as a Therapy Resistance Mechanism: Role of Melanoma SubpopulationsChemoprevention of MelanomaWhole genome and exome sequencing of melanoma: a step toward personalised targeted therapyTargeted Therapy for Gastric AdenocarcinomaHSP90 Inhibitors for Cancer Therapy and Overcoming Drug ResistanceApoptosis in Targeted Therapy Responses: The Role of BIM
- ISBN: 978-0-12-397927-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 576
- Fecha Publicación: 13/11/2012
- Nº Volúmenes: 1
- Idioma: Inglés