Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes MellitusIncludes a discussion of various strategies and techniques adopted for oral delivery of insulinPresents an update of research in the field INDICE: List of figures and tablesFiguresTables About the authors 1: Diabetes mellitus - an overviewAbstract1.1 Diabetes mellitus - an introduction1.2 Glucose homeostasis1.3 Types of diabetes1.4 Symptoms of diabetes1.5 Complications of diabetes1.6 Diagnosis of diabetes mellitus1.7 Therapy for diabetes1.8 Non-insulin treatment options of type 1 diabetes1.9 Treatment options of type 2 diabetes1.10 Conclusion 2: Routes of administration of insulinAbstract2.1 Current approach for the delivery of insulin2.2 Routes of administration of insulin2.3 Conclusion 3: Oral insulin delivery - challenges and strategiesAbstract3.1 Oral delivery of insulin3.2 Barriers to oral delivery of insulin3.3 Strategies and alternatives to improve oral insulin delivery3.4 Conclusion 4: Experimental techniques involved in the development of oral insulin carriersAbstract4.1 Introduction4.2 Polymeric nanoparticles4.3 Physicochemical characterization of nanoparticles4.4 Biological evaluation4.5 In vitro method for assessing drug permeability4.6 In vivo study of oral insulin4.7 Biodistribution studies4.8 Conclusion 5: Lipids and inorganic nanoparticles in oral insulin deliveryAbstract5.1 Lipid-based systems for oral delivery of insulin5.2 Liposomes5.3 Solid lipid nanoparticles5.4 Nanostructured lipid carriers5.5 Niosomes5.6 Archaeosomes5.7 Cubic nanoparticles (cubosomes)5.8 Aquasomes5.9 Inorganic nanoparticles as carriers for oral insulin delivery5.10 Conclusion 6: Polymers in oral insulin deliveryAbstract6.1 Introduction6.2 Characteristics of an ideal oral insulin carrier6.3 Polymers in oral insulin delivery6.4 Natural polymers6.5 Synthetic polymers6.6 Conclusion 7: Summary and future perspectives for oral insulin deliveryAbstract7.1 Introduction7.2 Technologies developed for clinical applications of oral insulin delivery7.3 Conclusions and future perspectives Index
- ISBN: 978-0-08-101625-1
- Editorial: Woodhead Publishing
- Encuadernacion: Rústica
- Páginas: 270
- Fecha Publicación: 30/06/2016
- Nº Volúmenes: 1
- Idioma: Inglés