Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity

This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. •    Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world •    Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models •    Discusses outcomes, epidemiology, real–life examples, and modes of action for arsenic–induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity •    Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up–to–date, novel modeling techniques for scientists •    Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure INDICE: Section I: Fundamentals of Arsenic Exposure and Metabolism .Chapter 1: History of Arsenic as a Poison and Medicinal 4 .Chapter 2: Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils – Distribution, Nature, Origin & Human Exposure Routes 34 .Chapter 3: Remediation of Arsenic in Drinking Water 115 .Chapter 4: The Chemistry and Metabolism of Arsenic 149 .Section II: Epidemiology and Disease Manifestations of Arsenic Exposure .Chapter 5: Human Population Studies and Nutritional Intervention 203 .Chapter 6: Skin manifestations of chronic arsenicosis 230 .Chapter 7: Lung cancer and other pulmonary diseases 247 .Chapter 8: Bladder Cancer and Arsenic 300 .Chapter 9: Neurological Effects of Arsenic Exposure 342 .Chapter 10: Diabetes Mellitus 387 .Chapter 11: Hepatotoxicity 428 .Chapter 12: Genetic Epidemiology of Susceptibility to Arsenic–induced Diseases 457 .Section III. Mechanisms of Toxicity .Chapter 13: Arsenic Interaction with Zinc Finger Motifs 501 .Chapter 14: Role In Chemotherapy 545 .Chapter 15: Genotoxicity 607 .Chapter 16: Arsenic and Signal Transduction 650 .Chapter 17: Stem Cell Targeting and Alteration by Arsenic 704 .Chapter 18: Epigenetics and Arsenic Toxicity 748 .Section IV: Models for Arsenic Toxicology, Risk Assessment .Chapter 19: Cancer Induced by Exposure to Arsenicals in Animals 779 .Chapter 20: Arsenic induced cardiovascular disease 804 .Chapter 21: Invertebrate Models in Arsenic Research: Past, Present & Future 835 .Chapter 22: Toxicokinetics and Pharmacokinetic Modelling of Arsenic 884 .Chapter 23: Considerations for a Biologically Based Risk Assessment for Arsenic 909 .Chapter 24: Translating experimental data to human populations 955

• ISBN: 978-1-118-51114-5
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 592
• Fecha Publicación: 25/11/2015
• Nº Volúmenes: 1
• Idioma: Inglés