Liver Disease in Children

The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease. INDICE: Preface; Part I. Pathophysiology of Pediatric Liver Disease: 1. Liver development Yiwei Zong and Joshua R. Friedman; 2. Functional development of the liver Frederick J. Suchy; 3. Mechanisms of bile formation and cholestasis Nitika A. Gupta and Saul J. Karpen; 4. Acute liver failure in children Robert H. Squires and Estella M. Alonso; 5. Cirrhosis and chronic liver failure Evelyn K. Hsu and Karen F. Murray; 6. Portal hypertension Benjamin L. Shneider; 7. Laboratory assessment of liver function and injury in children Vicky Lee Ng; Part II. Cholestatic Liver Disease: 8. Approach to the infant with cholestasis Amy Feldman and Frederick J. Suchy; 9. Medical and nutritional management of cholestasis in infants and children Andrew P. Feranchak, Frederick J. Suchy and Ronald J. Sokol; 10. Neonatal hepatitis and congenital infections Philip Rosenthal; 11. Biliary atresia and other disorders of the extrahepatic bile ducts William F. Balistreri, Jorge A. Bezerra and Frederick C. Ryckman; 12. Neonatal jaundice and disorders of bilirubin metabolism Mark Bartlett and Glenn R. Gourley; 13. Familial hepatocellular cholestasis Frederick J. Suchy, Shikha S. Sundaram and Benjamin L. Shneider; 14. Alagille syndrome Binita M. Kamath, Nancy B. Spinner and David A. Piccoli; 15. Intestinal failure associated liver disease Jason Soden and Ronald J. Sokol; 16. Disease of the gallbladder in infancy, childhood, and adolescence Frank W. DiPaola and James E. Heubi; Part III. Hepatitis and Immune Disorders: 17. Hepatitis A and hepatitis E virus infection Philip Rosenthal; 18. Hepatitis B virus infection Mei-Hwei Chang; 19. Hepatitis C virus infection Maureen M. Jonas; 20. Autoimmune hepatitis Nanda Kerkar and Cara L. Mack; 21. Sclerosing cholangitis Alexander G. Miethke and William F. Balistreri; 22. Drug-induced liver disease Eve A. Roberts; 23. Liver disease in immunodeficiencies Nedim Hadži?; Part IV. Metabolic Liver Disease: 24. Laboratory diagnosis of inborn errors of metabolism Piero Rinaldo; 25. ?1-antitrypsin deficiency David H. Perlmutter; 26. Cystic fibrosis liver disease Meghana Sathe and Andrew P. Feranchak; 27. Inborn errors of carbohydrate metabolism Rana F. Ammoury and Fayez K. Ghishan; 28. Copper metabolism and copper storage disorders Ronald J. Sokol; 29. Iron storage disorders Michael R. Narkewicz and Peter F. Whittington; 30. Heme biosynthesis and the porphyrias Robert J. Desnick, Manisha Balwani and Karl E. Anderson; 31. Tyrosinemia Grant Mitchell, Pierre A. Russo, Josée Dubois and Fernando Alvarez; 32. Lysosomal storage disorders T. Andrew Burrow and Gregory A. Grabowski; 33. Disorders of bile acid synthesis and metabolism Kenneth D. R. Setchell; 34. Inborn errors of fatty acid oxidation Melanie B. Gillingham and Robert B. Steiner; 35. Mitochondrial hepatopathies Ronald J. Sokol; 36. Nonalcoholic fatty liver disease in children Rohit Kohli, Kevin E. Bove and Stavra A. Xanthakos; 37. Peroxisomal diseases Paul A. Watkins and Kathleen B. Schwarz; 38. Urea cycle disorders Derek Wong and Stephen Cederbaum; Part V. Other Considerations and Issues in Pediatric Hepatology: 39. Bacterial, parasitic, and fungal infections of the liver Donald A. Novak, Gregory Y. Lauwers and Richard L. Kradin; 40. Systemic disease and the liver Kathleen M. Campbell; 41. Fibrocystic liver disease Ronen Arnon, Maureen M. Jonas, Antonio R. Perez-Atayde and Frederick J. Suchy; 42. Tumors of the liver Dolores López-Terrada and Milton J. Finegold; 43. Liver transplantation in children: indications and surgical aspects M. Kyle Jensen, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Gregory M. Tiao and William F. Balistreri; 44. Liver transplantation in children: post-transplant care Estella M. Alonso and Riccardo A. Superina; Index.

• ISBN: 978-1-107-01379-7
• Editorial: Cambridge University Press
• Encuadernacion: Cartoné
• Páginas: 752
• Fecha Publicación: 20/02/2014
• Nº Volúmenes: 1
• Idioma: Inglés