Drug design of zinc-enzyme inhibitors: functional, structural, and disease applications

The book focuses on zinc enzymes, some of which were intensively studied for more than six decades and translated into success stories of pharmaceutical industry that are models to follow for students and young researchers. Up-to-date oveviews on the major drug targets of the field (carbonic anhydrase, matrix metalloproteinases, bacterial proteases, angiotensin converting enzyme, histone deacetylase, LpxC, etc) are presented, showing the structural basis for catalysis, binding of inhibitors and activators, and their clinical applications. Emergent roles of some recently-discovered isozymes in cancer, obesity, epilepsy, pain management, malaria, etc are also introduced, together with the most recent achievements in drug design from both academia and industry. INDICE: Introduction. Drug design of carbonic anhydrase inhibitors and activators. Drug design of matrix metalloproteinase inhibitors. Drug design of bacterial zinc protease inhibitors. Drug design studies of other zinc-cotaining enzymes Index.

• ISBN: 978-0-470-27500-9
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 1022
• Fecha Publicación: 04/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés