TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trialsDiscusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and moreProvides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them INDICE: 1. Introduction2. Hereditary TRP Channelopathies3. Changes in TRP Channel Expression in Acquired Diseases4. TRP Gene Polymorphism and Disease Risk5. Topical Capsaicin for Pain Relief6. TRPV1 agonist cytotoxicity for chronic pain relief7. Intravesical Capsaicin and Resiniferatoxin for Bladder Disorders8. Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents 9. TRPA1 Antagonists for Pain Relief10. TRPA Antagonists as Therapeutic Strategies to Reduce the Symptoms and Pathophysiology of Respiratory Disorders11. TRPV3 Receptors as Drug Targets: A Decade of Learning12. TRPV4 Agonists and Antagonists13. Potential Therapeutic Applications for TRPV4 Antagonists in Lung Disease14. TRPM8 as a Target for Analgesia15. TRP Channels: Connectivity to Cerebral Vascular Disease16. TRP Channels' Key Role in the Transduction of Itch17. Role of TRP Channels in Skin Diseases18. TRP Channels in Obesity/Metabolic Syndrome19. TRP Channels in Diabetes20. TRP Channels and Ca²+ Entry in Cardiac Disease21. The Contribution of TRP Channels to Pathophysiological Regulation of the Gastrointestinal Tract22. Cancer: Oncogenic and Anti-Oncogenic TRP Channels as Biomarkers and Therapeutic Targets23. TRP Channels in the Brain24. A: Mucolipidosis and TRPML Channels24 B: TRPML1-dependent Processes as the Therapeutic Targets25. TRPs in respiratory disorders: opportunities beyond TRPA126. Concluding Remarks

• ISBN: 978-0-12-420024-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 448
• Fecha Publicación: 13/05/2015
• Nº Volúmenes: 1
• Idioma: Inglés