This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field INDICE: The Ras superfamily G-proteins Fuyuhiko TamanoiNMR Study to Identify a Ligand-Binding Pocket in Ras Till Maurer and Weiru WangThe Allosteric Switch and Conformational States in Ras GTPase Affected by Small MoleculesChristian W. Johnson and Carla MattosState 1(T) Inhibitors of Activated RasHans Robert Kalbitzer and Michael SpoernerSugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface Alessandro Di Domizio and Francesco Peri Development of EHop-016, a Small Molecule Inhibitor of RacSuranganie Dharmawardhane Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors Susanne Schmidt and Anne DebantTargeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways Anne Blangy and Philippe FortInhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPaseDominico Vigil and Channing J. DerA Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF InteractionVladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis Inhibitors of K-Ras Plasma Membrane LocalizationKwang-jin Cho, Dharini van der Hoeven and John F. Hancock Ras Chaperons: New Targets for Cancer and ImmunotherapyYoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor
- ISBN: 978-0-12-416749-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 364
- Fecha Publicación: 30/09/2013
- Nº Volúmenes: 1
- Idioma: Inglés