Drug Repurposing in Cancer Therapy: Approaches and Applications

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice about how existing drugs can be repurposed for cancer treatment. It summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. The book discusses specific topics such as in silico prediction and high throughput screening of repurposed drugs; drug repurposing for overcoming chemoresistance and eradicating cancer stem cells; and clinical investigation on combination of repurposed drug and anticancer therapy. This book is a valuable source for cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick but in-depth understanding about the current trends in drug repurposing researchBrings better understanding of drug repurposing process in a holistic way, combining both basic and clinical sciencesEncompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types, to stimulate further drug repurposing projects specific for individual tumor types INDICE: 1. General introduction of drug repurposing in cancer therapy2. Successful stories of drug repurposing for cancer therapy in major cancer types3. Identification of drug sensitizer? by drug repurposing to increase anticancer efficacy of classical cytotoxic drugs, radiotherapy, molecular targeted drugs, or immunotherapy4. Drug repurposing for eradicating cancer stem cells5. In silico approaches for identifying repurposed drugs for cancer therapy6. High-throughput screening strategies for identifying repurposed drugs for cancer therapy7. System biology approaches for identifying repurposed drugs for cancer therapy and for understanding of mechanisms8. Clinical trials on combination of repurposed drugs and anticancer therapies

• ISBN: 978-0-12-819668-7
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 04/10/2020
• Nº Volúmenes: 1
• Idioma: Inglés