The epigenetics of Autoimmunity is a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationships with the regulation of gene expression, and eventually to trigger immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression but also novel targets for potential epigenetic therapeutic treatment. Provides accurate and cutting-edge information on autoimmunity epigeneticsWide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interestsCritical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as it translational potentialUp-to-date coverage of emerging topics in autoimmunity epigenetics INDICE: 1. The epigenetics of autoimmunity: An Overview 2. Immune cell development and epigenetics 3. DNA methylation and histone modifications of the immune system 4. MicroRNA and T helper cell-mediated immune response 5. Long non-coding RNAs in the immune response 6. Systemic Lupus Erythematosus and Epigenetics 7. Rheumatoid Arthritis and Epigenetics 8. Multiple Sclerosis and Epigenetics 9. Type 1 Diabetes and Epigenetics 10. Systemic Sclerosis and Epigenetics 11. Primary Sjögren's Syndrome and Epigenetics 12. Autoimmune Thyroid Diseases and Epigenetics 13. Primary Biliary Cirrhosis and Epigenetics 14. Immune-mediated Pulmonary Diseases and Epigenetics 15. Autoimmunity Epigenetics and Epigenetic Drug Development 16. Applications of T Cell Vaccination for Autoimmune Diseases 17. Therapeutic targeting of microRNAs current status and future challenges 18. Future Challenges and Prospects for Epigenetics of Autoimmunity
- ISBN: 978-0-12-809912-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 464
- Fecha Publicación: 01/08/2018
- Nº Volúmenes: 1
- Idioma: Inglés