Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processesEncompasses both foundational and clinical aspects including discussions of preventative in utero therapiesCovers history, future outlook, disease management and current controversies INDICE: Transgenerational EpigeneticsHistorical Perspective of Transgenerational EpigeneticsEpidemiology of Transgenerational EpigeneticsMetastable EpiallelsParamutationsEpigenetic Silencing of TransgenesEpigenetic Inheritance of Repeat SequencesHistone-mediated Transgenerational EpigeneticsHeritable Generational Effects Through RNAAnimal Models of Transgenerational Epigenetic EffectsPlant Models of Transgnerational Epigenetic InheritanceTransgenerational Epigenetic Effects in PlantsMaternal Epigenetic InheritancePaternal Epigenetic InheritanceEvolution of Transgenerational Epigenetic InheritanceHeritable Epigenetics Over Multiple GenerationsMaternal Stress Effects on Transgenerational EpigeneticsPreimplantation Environment and Epigenetic Transgenerational InheritanceTransgenerational Epigenetic Inheritance and Human DiseaseEnvironmental Transgenerational Epigenetic EffectsTransgenerational Epigenetics of Endocrine DisruptorsEffects of Transgenerational Epigenetics on LongevityTransgenerational Epigenetic Effects of an Environmental Enrichment on Memory FormationDietary Effects on Transgenerational Epigenetic InheritanceClinical Applications of Transgenerational EpigeneticsTransgenerational Epigenetics: Current ControversiesFuture Directions of Transgenerational Epigenetic Research
- ISBN: 978-0-12-405944-3
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 406
- Fecha Publicación: 01/08/2014
- Nº Volúmenes: 1
- Idioma: Inglés