In our ideal view of metabolism we think of catabolism and anabolism. In catabolism nutrients are break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients are break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sport medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Overflow Metabolism: From Bacteria to Marathon Runners provides an overview of overflow metabolism. The major phenomenological aspects of overflow metabolism are first reviewed, as observed in different organisms followed by a critical analysis of proposed theories to explain overflow metabolism. Examples of overflow metabolism and major phenomenological features are includedA critical view of proposed theories to explain overflow metabolismA summary of our previews work proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results INDICE: 1. Catabolism, anabolism and overflow 2. Pasteur, Warburg and Crabtree 3. The chemostat experiment 4. Biochemical horsepower 5. The Marathon world record 6. How fast can a cell grow? 7. Metabolic neurodegeneration
- ISBN: 978-0-12-812208-2
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 150
- Fecha Publicación: 01/01/2018
- Nº Volúmenes: 1
- Idioma: Inglés