This book examines the current evidence and research supporting the importance of oxidative injury in selected animal models of both neurodegenerative diseases and neural injury. Each chapter discusses oxidative injury in a selected model, analyzing the major cellular mechanisms that underpin the progression of neural injury. In addition to the analysis of these models, each chapter’s purpose is to not only relate, but to also contrast the specific injury across models as a way of identifying the common and unique pathways of oxidative neural injury. Through this, each author presents possible fertile future directions for translational research for the identification of possible therapeutics. INDICE: Basic Redox (reactive oxygen/nitrogen species) Biochemistry.- Areas of neuronal loss in hypoixa/reoxygenation oxidative injury.- How oxidative injury translates into unfolded protein response-induced cellular dysfunction.-Mitochondrial injury as a source of oxidative injury to neurons in amyotrophic lateral sclerosis.- Oxidative injury to the autonomic nervous system.- Excitatory neurotoxicity and ER stress component (Therapeutics part).- Excitatory neurotoxicity and ER stress component (Therapeutics part).- ROS and brain injury in alzheimer’s.- Oxidative neural injury in Parkinson’s.- Oxidative neural injury in sleep apnea.- PPAR oxidative response in neurodegenerative disorders.- Neuronal injury and oxidative across disease.
- ISBN: 978-1-60327-341-1
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 170
- Fecha Publicación: 01/06/2009
- Nº Volúmenes: 1
- Idioma: Inglés